Nucleotide excision repair (NER) is the most versatile and best studied DNA repair system in
humans. NER can repair a variety of bulky DNA damages including UV-light induced DNA …

The XPG/ERCC5 endonuclease was originally identified as the causative gene for
Xeroderma Pigmentosum complementation group G. Ever since its discovery, in depth …

Loss of a nonenzymatic function of XPG results in defective transcription-coupled repair
(TCR), Cockayne syndrome (CS), and early death, but the molecular basis for these …

To address the biochemical mechanisms underlying the coordination between the various
proteins required for nucleotide excision repair (NER), we employed the immobilized …

Accumulation of DNA lesions causing transcription stress is associated with natural and
accelerated aging and culminates with profound metabolic alterations. Our understanding of …

PIN-like domains constitute a widespread superfamily of nucleases, diverse in terms of the
reaction mechanism, substrate specificity, biological function and taxonomic distribution …

Nucleotide excision repair factors, initially characterized as part of DNA repair, have been
shown to participate in the transcriptional process in the absence of genotoxic attack …

Xeroderma pigmentosum group G (XPG) protein is both a functional partner in multiple DNA
damage responses (DDR) and a pathway coordinator and structure-specific endonuclease …

Eukaryotic cells respond to a variety of DNA insults by triggering a common signal
transduction cascade, known as checkpoint response, which temporarily halts cell-cycle …

We studied three newly diagnosed xeroderma pigmentosum complementation group G
patients with markedy different clinical features. An Israeli-Palestinian girl (XP96TA) had …