Uncovering the complexity of transcriptomes with RNA‐Seq
In recent years, the introduction of massively parallel sequencing platforms for Next
Generation Sequencing (NGS) protocols, able to simultaneously sequence hundred …
Generation Sequencing (NGS) protocols, able to simultaneously sequence hundred …
A comparison of statistical methods for detecting differentially expressed genes from RNA‐seq data
VM Kvam, P Liu, Y Si - American journal of botany, 2012 - Wiley Online Library
RNA‐Seq technologies are quickly revolutionizing genomic studies, and statistical methods
for RNA‐seq data are under continuous development. Timely review and comparison of the …
for RNA‐seq data are under continuous development. Timely review and comparison of the …
Differential analysis of gene regulation at transcript resolution with RNA-seq
Differential analysis of gene and transcript expression using high-throughput RNA
sequencing (RNA-seq) is complicated by several sources of measurement variability and …
sequencing (RNA-seq) is complicated by several sources of measurement variability and …
[HTML][HTML] Self-recognition of an inducible host lncRNA by RIG-I feedback restricts innate immune response
M Jiang, S Zhang, Z Yang, H Lin, J Zhu, L Liu, W Wang… - Cell, 2018 - cell.com
The innate RNA sensor RIG-I is critical in the initiation of antiviral type I interferons (IFNs)
production upon recognition of" non-self" viral RNAs. Here, we identify a host-derived, IFN …
production upon recognition of" non-self" viral RNAs. Here, we identify a host-derived, IFN …
Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
High-throughput mRNA sequencing (RNA-Seq) promises simultaneous transcript discovery
and abundance estimation,,. However, this would require algorithms that are not restricted …
and abundance estimation,,. However, this would require algorithms that are not restricted …
Transcriptome genetics using second generation sequencing in a Caucasian population
SB Montgomery, M Sammeth, M Gutierrez-Arcelus… - Nature, 2010 - nature.com
Gene expression is an important phenotype that informs about genetic and environmental
effects on cellular state. Many studies have previously identified genetic variants for gene …
effects on cellular state. Many studies have previously identified genetic variants for gene …
Characterization of the human ESC transcriptome by hybrid sequencing
KF Au, V Sebastiano, PT Afshar… - Proceedings of the …, 2013 - National Acad Sciences
Although transcriptional and posttranscriptional events are detected in RNA-Seq data from
second-generation sequencing, full-length mRNA isoforms are not captured. On the other …
second-generation sequencing, full-length mRNA isoforms are not captured. On the other …
[HTML][HTML] Transcript assembly and abundance estimation from RNA-Seq reveals thousands of new transcripts and switching among isoforms
C Trapnell, BA Williams, G Pertea, A Mortazavi… - Nature …, 2010 - ncbi.nlm.nih.gov
High-throughput mRNA sequencing (RNA-Seq) holds the promise of simultaneous transcript
discovery and abundance estimation 1-3. We introduce an algorithm for transcript assembly …
discovery and abundance estimation 1-3. We introduce an algorithm for transcript assembly …
[HTML][HTML] RNA-seq: technical variability and sampling
Background RNA-seq is revolutionizing the way we study transcriptomes. mRNA can be
surveyed without prior knowledge of gene transcripts. Alternative splicing of transcript …
surveyed without prior knowledge of gene transcripts. Alternative splicing of transcript …
The study of eQTL variations by RNA-seq: from SNPs to phenotypes
J Majewski, T Pastinen - Trends in Genetics, 2011 - cell.com
Common DNA variants alter the expression levels and patterns of many human genes. Loci
responsible for this genetic control are known as expression quantitative trait loci (eQTLs) …
responsible for this genetic control are known as expression quantitative trait loci (eQTLs) …