Although asthma is an inflammatory disorder of the conducting airways involving TH2-type T
cells, there is increasing evidence for an important role played by the epithelium in …

The activation of immune-defense mechanisms in response to a microbial attack must be
robust and appropriately tailored to fight particular types of pathogens. Infection with …

Both structural and inflammatory cells are capable of secreting transforming growth factor
(TGF)‐β and expressing TGF‐β receptors. TGF‐β can induce multiple cellular responses …

Although histologic features of airway remodeling have been well characterized in asthma,
the immunologic and inflammatory mechanisms that drive progression of asthma to …

Asthmatic airway remodeling is the pathophysiological modifications of the normal airway
wall structure which include changes in the composition and organization of its cellular and …

Abstract Knowledge of genetic origins of obstructive lung diseases has made inhaled gene
therapy an attractive alternative to the current standards of care that are limited to managing …

Airway remodeling is accepted to be a determining component within the natural history of
asthma. It is a phenomenon characterized by changes in the airways structures that marches …

Chronic allergic asthma is characterized by Th2-typed inflammation, and contributes to
airway remodeling and the deterioration of lung function. However, the initiating factor that …

The purpose of this review is to collate current knowledge and recent advances in molecular
mechanism behind the immediate type hypersensitivity of foods. Food allergy is a growing …

In refractory asthma, neutrophils, rather than eosinophils, often predominate in the airways.
Neutrophilic airway inflammation appears to be resistant to steroids and may be related to …