Epithelium dysfunction in asthma
ST Holgate - Journal of Allergy and Clinical Immunology, 2007 - Elsevier
Although asthma is an inflammatory disorder of the conducting airways involving TH2-type T
cells, there is increasing evidence for an important role played by the epithelium in …
cells, there is increasing evidence for an important role played by the epithelium in …
T-bet in disease
V Lazarevic, LH Glimcher - Nature immunology, 2011 - nature.com
The activation of immune-defense mechanisms in response to a microbial attack must be
robust and appropriately tailored to fight particular types of pathogens. Infection with …
robust and appropriately tailored to fight particular types of pathogens. Infection with …
The regulatory role of TGF‐β in airway remodeling in asthma
T Makinde, RF Murphy… - Immunology and cell …, 2007 - Wiley Online Library
Both structural and inflammatory cells are capable of secreting transforming growth factor
(TGF)‐β and expressing TGF‐β receptors. TGF‐β can induce multiple cellular responses …
(TGF)‐β and expressing TGF‐β receptors. TGF‐β can induce multiple cellular responses …
Immunologic and inflammatory mechanisms that drive asthma progression to remodeling
DH Broide - Journal of allergy and clinical immunology, 2008 - Elsevier
Although histologic features of airway remodeling have been well characterized in asthma,
the immunologic and inflammatory mechanisms that drive progression of asthma to …
the immunologic and inflammatory mechanisms that drive progression of asthma to …
Airway remodeling in asthma
R Halwani, S Al-Muhsen, Q Hamid - Current opinion in pharmacology, 2010 - Elsevier
Asthmatic airway remodeling is the pathophysiological modifications of the normal airway
wall structure which include changes in the composition and organization of its cellular and …
wall structure which include changes in the composition and organization of its cellular and …
Barriers to inhaled gene therapy of obstructive lung diseases: A review
Abstract Knowledge of genetic origins of obstructive lung diseases has made inhaled gene
therapy an attractive alternative to the current standards of care that are limited to managing …
therapy an attractive alternative to the current standards of care that are limited to managing …
Immune induction of airway remodeling
Airway remodeling is accepted to be a determining component within the natural history of
asthma. It is a phenomenon characterized by changes in the airways structures that marches …
asthma. It is a phenomenon characterized by changes in the airways structures that marches …
Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite
ZG Chen, TT Zhang, HT Li, FH Chen, XL Zou, JZ Ji… - PloS one, 2013 - journals.plos.org
Chronic allergic asthma is characterized by Th2-typed inflammation, and contributes to
airway remodeling and the deterioration of lung function. However, the initiating factor that …
airway remodeling and the deterioration of lung function. However, the initiating factor that …
Molecular mechanisms of IgE mediated food allergy
The purpose of this review is to collate current knowledge and recent advances in molecular
mechanism behind the immediate type hypersensitivity of foods. Food allergy is a growing …
mechanism behind the immediate type hypersensitivity of foods. Food allergy is a growing …
Transcription factors GATA-3 and RORγt are important for determining the phenotype of allergic airway inflammation in a murine model of asthma
S Ano, Y Morishima, Y Ishii, K Yoh… - The Journal of …, 2013 - journals.aai.org
In refractory asthma, neutrophils, rather than eosinophils, often predominate in the airways.
Neutrophilic airway inflammation appears to be resistant to steroids and may be related to …
Neutrophilic airway inflammation appears to be resistant to steroids and may be related to …