Recombinant protein vaccines, a proven approach against coronavirus pandemics

J Pollet, WH Chen, U Strych - Advanced drug delivery reviews, 2021 - Elsevier
With the COVID-19 pandemic now ongoing for close to a year, people all over the world are
still waiting for a vaccine to become available. The initial focus of accelerated global …

Glycomics and glycoproteomics of viruses: Mass spectrometry applications and insights toward structure–function relationships

JF Cipollo, LM Parsons - Mass spectrometry reviews, 2020 - Wiley Online Library
The advancement of viral glycomics has paralleled that of the mass spectrometry glycomics
toolbox. In some regard the glycoproteins studied have provided the impetus for this …

Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques

L Huang, T Zhao, W Zhao, A Shao, H Zhao… - Emerging Microbes & …, 2024 - Taylor & Francis
Herpes zoster remains an important global health issue and mainly occurs in aged and
immunocompromised individuals with an early exposure history to Varicella Zoster Virus …

A nanoparticle vaccine displaying varicella-zoster virus gE antigen induces a superior cellular immune response than a licensed vaccine in mice and non-human …

Y Li, S Tian, Y Ai, Z Hu, C Ma, M Fu, Z Xu, Y Li… - Frontiers in …, 2024 - frontiersin.org
Herpes zoster (HZ), also known as shingles, remains a significant global health issue and
most commonly seen in elderly individuals with an early exposure history to varicella-zoster …

H84T BanLec has broad spectrum antiviral activity against human herpesviruses in cells, skin, and mice

MG Lloyd, D Liu, M Legendre, DM Markovitz… - Scientific Reports, 2022 - nature.com
H84T BanLec is a molecularly engineered lectin cloned from bananas with broad-spectrum
antiviral activity against several RNA viruses. H84T BanLec dimers bind glycoproteins …

Sialic acid and fucose residues on the SARS-CoV-2 receptor-binding domain modulate IgG antibody reactivity

E Samuelsson, E Mirgorodskaya, K Nystrom… - ACS Infectious …, 2022 - ACS Publications
The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is a conserved
domain and a target for neutralizing antibodies. We defined the carbohydrate content of the …

A Synergistic Lipid Nanoparticle Encapsulating mRNA Shingles Vaccine Induces Potent Immune Responses and Protects Guinea Pigs from Viral Challenges

X Cheng, S Liu, J Sun, L Liu, X Ma, J Li… - Advanced …, 2024 - Wiley Online Library
Shingles is caused by the reactivation of varicella zoster virus (VZV) and manifests as
painful skin rashes. While the recombinant protein‐based vaccine proves highly effective, it …

Structure and Role of O-Linked Glycans in Viral Envelope Proteins

S Olofsson, M Bally, E Trybala… - Annual review of …, 2023 - annualreviews.org
N-and O-glycans are both important constituents of viral envelope glycoproteins. O-linked
glycosylation can be initiated by any of 20 different human polypeptide O …

Advances in alpha herpes viruses vaccines for human

M Preda, LSC Manolescu, RD Chivu - Vaccines, 2023 - mdpi.com
Alpha herpes simplex viruses are an important public health problem affecting all age
groups. It can produce from common cold sores and chicken pox to severe conditions like …

The use of proteins and peptides-based therapy in managing and preventing pathogenic viruses

EM El-Fakharany, H El-Gendi, AK Saleh… - International Journal of …, 2024 - Elsevier
Therapeutic proteins have been employed for centuries and reached approximately 50% of
all drugs investigated. By 2023, they represented one of the top 10 largest-selling pharma …