ERK1/2 in immune signalling
Extracellular signal-related kinases 1 and 2 (ERK1/2) are the final components of the
mitogen-activated protein kinase (MAPK) phosphorylation cascade, an integral module in a …
mitogen-activated protein kinase (MAPK) phosphorylation cascade, an integral module in a …
Trial Watch: Toll-like receptor agonists in cancer immunotherapy
M Smith, E García-Martínez, MR Pitter… - …, 2018 - Taylor & Francis
Toll-like receptor (TLR) agonists demonstrate therapeutic promise as immunological
adjuvants for anticancer immunotherapy. To date, three TLR agonists have been approved …
adjuvants for anticancer immunotherapy. To date, three TLR agonists have been approved …
[HTML][HTML] Multi-organ proteomic landscape of COVID-19 autopsies
X Nie, L Qian, R Sun, B Huang, X Dong, Q Xiao… - Cell, 2021 - cell.com
The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …
Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation
S Zewinger, J Reiser, V Jankowski, D Alansary… - Nature …, 2020 - nature.com
NLRP3-inflammasome-driven inflammation is involved in the pathogenesis of a variety of
diseases. Identification of endogenous inflammasome activators is essential for the …
diseases. Identification of endogenous inflammasome activators is essential for the …
[HTML][HTML] Recent advances in the development of toll-like receptor agonist-based vaccine adjuvants for infectious diseases
JX Yang, JC Tseng, GY Yu, Y Luo, CYF Huang… - Pharmaceutics, 2022 - mdpi.com
Vaccines are powerful tools for controlling microbial infections and preventing epidemic
diseases. Efficient inactive, subunit, or viral-like particle vaccines usually rely on a safe and …
diseases. Efficient inactive, subunit, or viral-like particle vaccines usually rely on a safe and …
Genome‐wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks …
Abstract Introduction Large variability among Alzheimer's disease (AD) cases might impact
genetic discoveries and complicate dissection of underlying biological pathways. Methods …
genetic discoveries and complicate dissection of underlying biological pathways. Methods …
[HTML][HTML] Tissue-specific transcriptional profiles and heterogeneity of natural killer cells and group 1 innate lymphoid cells
N Lopes, J Galluso, B Escaliere, S Carpentier… - Cell Reports …, 2022 - cell.com
Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are populations of non-T,
non-B lymphocytes in peripheral tissues. Although NK and ILC1 subsets have been …
non-B lymphocytes in peripheral tissues. Although NK and ILC1 subsets have been …
Genomics of Alzheimer's disease implicates the innate and adaptive immune systems
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterised by cognitive
impairment, behavioural alteration, and functional decline. Over 130 AD-associated …
impairment, behavioural alteration, and functional decline. Over 130 AD-associated …
[HTML][HTML] A high resolution atlas of gene expression in the domestic sheep (Ovis aries)
Sheep are a key source of meat, milk and fibre for the global livestock sector, and an
important biomedical model. Global analysis of gene expression across multiple tissues has …
important biomedical model. Global analysis of gene expression across multiple tissues has …
[HTML][HTML] Exosomal secreted SCIMP regulates communication between macrophages and neutrophils in pneumonia
X Pei, L Liu, J Wang, C Guo, Q Li, J Li, Q Ren… - Nature …, 2024 - nature.com
In pneumonia, the deficient or delayed pathogen clearance can lead to pathogen
proliferation and subsequent overactive immune responses, inducing acute lung injury (ALI) …
proliferation and subsequent overactive immune responses, inducing acute lung injury (ALI) …