EZH1/2 as targets for cancer therapy
R An, YQ Li, YL Lin, F Xu, MM Li, Z Liu - Cancer Gene Therapy, 2023 - nature.com
The enhancer of zeste homolog 2 (EZH2) and its highly related homolog EZH1 are
considered to be epigenetic silencing factors, and they play key roles in the growth and …
considered to be epigenetic silencing factors, and they play key roles in the growth and …
[HTML][HTML] High mobility group A1 (HMGA1): structure, biological function, and therapeutic potential
L Wang, J Zhang, M Xia, C Liu, X Zu… - International journal of …, 2022 - ncbi.nlm.nih.gov
High mobility group A1 (HMGA1) is a nonhistone chromatin structural protein characterized
by no transcriptional activity. It mainly plays a regulatory role by modifying the structure of …
by no transcriptional activity. It mainly plays a regulatory role by modifying the structure of …
Drug-induced inhibition of HMGA and EZH2 activity as a possible therapy for anaplastic thyroid carcinoma
M De Martino, S Pellecchia, M Decaussin-Petrucci… - Cell Cycle, 2023 - Taylor & Francis
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and lethal neoplasms in
humans, and just limited progresses have been made to extend patient survival and …
humans, and just limited progresses have been made to extend patient survival and …
Critical role of the high mobility group A proteins in hematological malignancies
M De Martino, F Esposito, A Fusco - Hematological Oncology, 2022 - Wiley Online Library
The high mobility group A (HMGA) protein family is composed of three non‐histone
chromatin remodeling proteins that act as architectural transcriptional factors. Indeed …
chromatin remodeling proteins that act as architectural transcriptional factors. Indeed …
[HTML][HTML] HMGA1 is a Prognostic Biomarker and Correlated with Glycolysis in Lung Adenocarcinoma
Y Ma, XY Ma, BL Du, XN Li, YM Li - Journal of Cancer, 2024 - ncbi.nlm.nih.gov
Purpose: Lung cancer is one of the leading causes with high morbidity and mortality. High
mobility group A1 (HMGA1) protein participates in the process of tumorigenesis. This study …
mobility group A1 (HMGA1) protein participates in the process of tumorigenesis. This study …
The role of HMGA1 protein in gastroenteropancreatic neuroendocrine tumors
M De Martino, S Pellecchia, F Esposito, N Tosti… - Cell Cycle, 2022 - Taylor & Francis
Neuroendocrine tumors (NETs) are neoplasms derived from neuroendocrine cells. One of
their main features is to often remain asymptomatic and clinically undetectable. High Mobility …
their main features is to often remain asymptomatic and clinically undetectable. High Mobility …