Topoisomerase I inhibitors: camptothecins and beyond
Y Pommier - Nature Reviews Cancer, 2006 - nature.com
Abstract Nuclear DNA topoisomerase I (TOP1) is an essential human enzyme. It is the only
known target of the alkaloid camptothecin, from which the potent anticancer agents …
known target of the alkaloid camptothecin, from which the potent anticancer agents …
Type i DNA topoisomerases
G Capranico, J Marinello… - Journal of medicinal …, 2017 - ACS Publications
DNA topoisomerases constitute a large family of enzymes that are essential for all domains
of life. Although they share general reaction chemistry and the capacity to govern DNA …
of life. Although they share general reaction chemistry and the capacity to govern DNA …
RNA/DNA hybrid interactome identifies DXH9 as a molecular player in transcriptional termination and R-loop-associated DNA damage
R-loops comprise an RNA/DNA hybrid and displaced single-stranded DNA. They play
important biological roles and are implicated in pathology. Even so, proteins recognizing …
important biological roles and are implicated in pathology. Even so, proteins recognizing …
RNA polymerase II regulates topoisomerase 1 activity to favor efficient transcription
L Baranello, D Wojtowicz, K Cui, BN Devaiah… - Cell, 2016 - cell.com
We report a mechanism through which the transcription machinery directly controls
topoisomerase 1 (TOP1) activity to adjust DNA topology throughout the transcription cycle …
topoisomerase 1 (TOP1) activity to adjust DNA topology throughout the transcription cycle …
Rates of in situ transcription and splicing in large human genes
J Singh, RA Padgett - Nature structural & molecular biology, 2009 - nature.com
Transcription and splicing must proceed over genomic distances of hundreds of kilobases in
many human genes. However, the rates and mechanisms of these processes are poorly …
many human genes. However, the rates and mechanisms of these processes are poorly …
DNA Topoisomerase I differentially modulates R-loops across the human genome
Background Co-transcriptional R-loops are abundant non-B DNA structures in mammalian
genomes. DNA Topoisomerase I (Top1) is often thought to regulate R-loop formation owing …
genomes. DNA Topoisomerase I (Top1) is often thought to regulate R-loop formation owing …
Transcriptional firing helps to drive NETosis
MA Khan, N Palaniyar - Scientific reports, 2017 - nature.com
Neutrophils are short-lived innate immune cells. These cells respond quickly to stimuli, and
die within minutes to hours; the relevance of DNA transcription in dying neutrophils remains …
die within minutes to hours; the relevance of DNA transcription in dying neutrophils remains …
Transcription-dependent dynamic supercoiling is a short-range genomic force
F Kouzine, A Gupta, L Baranello, D Wojtowicz… - Nature structural & …, 2013 - nature.com
Transcription has the capacity to mechanically modify DNA topology, DNA structure and
nucleosome arrangement. Resulting from ongoing transcription, these modifications in turn …
nucleosome arrangement. Resulting from ongoing transcription, these modifications in turn …
Cotranscriptional coupling of splicing factor recruitment and precursor messenger RNA splicing in mammalian cells
I Listerman, AK Sapra, KM Neugebauer - Nature structural & molecular …, 2006 - nature.com
Coupling between transcription and RNA processing is a key gene regulatory mechanism.
Here we use chromatin immunoprecipitation to detect transcription-dependent accumulation …
Here we use chromatin immunoprecipitation to detect transcription-dependent accumulation …
Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors
MT Tomicic, B Kaina - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2013 - Elsevier
Topoisomerase I (TOP1) inhibitors applied in cancer therapy such as topotecan and
irinotecan are derivatives of the natural alkaloid camptothecin (CPT). The mechanism of …
irinotecan are derivatives of the natural alkaloid camptothecin (CPT). The mechanism of …