Dopamine, immunity, and disease

B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - ASPET
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Astrocytes in the initiation and progression of epilepsy

A Vezzani, T Ravizza, P Bedner, E Aronica… - Nature Reviews …, 2022 - nature.com
Epilepsy affects~ 65 million people worldwide. First-line treatment options include> 20
antiseizure medications, but seizure control is not achieved in approximately one-third of …

The link between neuroinflammation and the neurovascular unit in synucleinopathies

Q Wang, J Zheng, S Pettersson, R Reynolds… - Science advances, 2023 - science.org
The neurovascular unit (NVU) is composed of vascular cells, glial cells, and neurons. As a
fundamental functional module in the central nervous system, the NVU maintains …

PET imaging of neuroinflammation in Alzheimer's disease

R Zhou, B Ji, Y Kong, L Qin, W Ren, Y Guan… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammation play an important role in Alzheimer's disease pathogenesis. Advances in
molecular imaging using positron emission tomography have provided insights into the time …

The pathogenesis of Parkinson's disease: a complex interplay between astrocytes, microglia, and T lymphocytes?

AN MacMahon Copas, SF McComish… - Frontiers in …, 2021 - frontiersin.org
Parkinson's disease (PD), the second most common neurodegenerative disease, is
characterised by the motor symptoms of bradykinesia, rigidity and resting tremor and non …

Microglia and astrocyte function and communication: what do we know in humans?

EF Garland, IJ Hartnell, D Boche - Frontiers in neuroscience, 2022 - frontiersin.org
Microglia and astrocytes play essential roles in the central nervous system contributing to
many functions including homeostasis, immune response, blood–brain barrier maintenance …

Neuropathology of incidental Lewy body & prodromal Parkinson's disease

T Koeglsperger, SL Rumpf, P Schließer… - Molecular …, 2023 - Springer
Background Parkinson's disease (PD) is a progressive neurodegenerative disorder
associated with a loss of dopaminergic (DA) neurons. Despite symptomatic therapies, there …

Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson's disease model

G Morrone Parfitt, E Coccia, C Goldman… - Nature …, 2024 - nature.com
Accumulation of advanced glycation end products (AGEs) on biopolymers accompanies
cellular aging and drives poorly understood disease processes. Here, we studied how AGEs …

PET neuroimaging of Alzheimer's disease: radiotracers and their utility in clinical research

W Bao, F Xie, C Zuo, Y Guan… - Frontiers in aging …, 2021 - frontiersin.org
Alzheimer's Disease (AD), the leading cause of senile dementia, is a progressive
neurodegenerative disorder affecting millions of people worldwide and exerting tremendous …

Positron emission tomography in multiple sclerosis—straight to the target

B Bodini, M Tonietto, L Airas, B Stankoff - Nature reviews Neurology, 2021 - nature.com
Following the impressive progress in the treatment of relapsing–remitting multiple sclerosis
(MS), the major challenge ahead is the development of treatments to prevent or delay the …