Dopamine, immunity, and disease
B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - ASPET
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …
regulating many processes including reward, movement, and cognition. Dopamine also …
Astrocytes in the initiation and progression of epilepsy
Epilepsy affects~ 65 million people worldwide. First-line treatment options include> 20
antiseizure medications, but seizure control is not achieved in approximately one-third of …
antiseizure medications, but seizure control is not achieved in approximately one-third of …
The link between neuroinflammation and the neurovascular unit in synucleinopathies
The neurovascular unit (NVU) is composed of vascular cells, glial cells, and neurons. As a
fundamental functional module in the central nervous system, the NVU maintains …
fundamental functional module in the central nervous system, the NVU maintains …
PET imaging of neuroinflammation in Alzheimer's disease
R Zhou, B Ji, Y Kong, L Qin, W Ren, Y Guan… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammation play an important role in Alzheimer's disease pathogenesis. Advances in
molecular imaging using positron emission tomography have provided insights into the time …
molecular imaging using positron emission tomography have provided insights into the time …
The pathogenesis of Parkinson's disease: a complex interplay between astrocytes, microglia, and T lymphocytes?
AN MacMahon Copas, SF McComish… - Frontiers in …, 2021 - frontiersin.org
Parkinson's disease (PD), the second most common neurodegenerative disease, is
characterised by the motor symptoms of bradykinesia, rigidity and resting tremor and non …
characterised by the motor symptoms of bradykinesia, rigidity and resting tremor and non …
Microglia and astrocyte function and communication: what do we know in humans?
EF Garland, IJ Hartnell, D Boche - Frontiers in neuroscience, 2022 - frontiersin.org
Microglia and astrocytes play essential roles in the central nervous system contributing to
many functions including homeostasis, immune response, blood–brain barrier maintenance …
many functions including homeostasis, immune response, blood–brain barrier maintenance …
Neuropathology of incidental Lewy body & prodromal Parkinson's disease
T Koeglsperger, SL Rumpf, P Schließer… - Molecular …, 2023 - Springer
Background Parkinson's disease (PD) is a progressive neurodegenerative disorder
associated with a loss of dopaminergic (DA) neurons. Despite symptomatic therapies, there …
associated with a loss of dopaminergic (DA) neurons. Despite symptomatic therapies, there …
Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson's disease model
Accumulation of advanced glycation end products (AGEs) on biopolymers accompanies
cellular aging and drives poorly understood disease processes. Here, we studied how AGEs …
cellular aging and drives poorly understood disease processes. Here, we studied how AGEs …
PET neuroimaging of Alzheimer's disease: radiotracers and their utility in clinical research
W Bao, F Xie, C Zuo, Y Guan… - Frontiers in aging …, 2021 - frontiersin.org
Alzheimer's Disease (AD), the leading cause of senile dementia, is a progressive
neurodegenerative disorder affecting millions of people worldwide and exerting tremendous …
neurodegenerative disorder affecting millions of people worldwide and exerting tremendous …
Positron emission tomography in multiple sclerosis—straight to the target
Following the impressive progress in the treatment of relapsing–remitting multiple sclerosis
(MS), the major challenge ahead is the development of treatments to prevent or delay the …
(MS), the major challenge ahead is the development of treatments to prevent or delay the …