Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …

In recent years, rapid discoveries have been made relating to Ca 2+ handling at specific
organelles that have important implications for whole-cell Ca 2+ homeostasis. In particular …

Metabolic reprogramming in tumours is now recognized as a hallmark of cancer,
participating both in tumour growth and cancer progression. Cancer cells develop global …

Mitochondrial Ca 2+ regulation is crucial for bioenergetics and cellular signaling. The
mechanisms controlling mitochondrial calcium homeostasis have been recently unraveled …

The interplay between Ca 2+ and reactive oxygen species (ROS) signaling pathways is well
established, with reciprocal regulation occurring at a number of subcellular locations. Many …

Triple‐negative breast cancer (TNBC) represents the most aggressive breast tumor subtype.
However, the molecular determinants responsible for the metastatic TNBC phenotype are …

In addition to their role in providing cellular energy, mitochondria fulfill a key function in
cellular calcium management. The present review provides an integrative view of cellular …

Mitochondrial Ca 2+ signaling, which is strongly dependent on the mitochondrial Ca 2+
uniporter (MCU) complex, has a series of key roles in physiopathological processes …

Mitochondrial calcium uniporter (MCU) has an important role in regulating mitochondrial
calcium (Ca2+) homeostasis. Dysregulation of mitochondrial Ca2+ homeostasis has been …

Although mitochondrial contributions to cancer have been recognised for approximately a
century, given that mitochondrial DNA (mtDNA) is dwarfed by the size of the nuclear genome …