Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …

Interleukin-6 (IL-6) is a pleiotropic cytokine with roles in immunity, tissue regeneration, and
metabolism. Rapid production of IL-6 contributes to host defense during infection and tissue …

Rationale: It is assumed that atherosclerotic arteries contain several macrophage subsets
endowed with specific functions. The precise identity of these subsets is poorly …

INTRODUCTION Cytotoxic T lymphocytes (CTLs) are important cells within the immune
system that are able to recognize and destroy cancer and virally infected cells. Killing is …

Phenotypic polarization of macrophages is regulated by a milieu of cues in the local tissue
microenvironment. Currently, little is known about how the intrinsic regulators modulate …

Autoimmunity and autoinflammation arise from aberrant immunological and inflammatory
responses toward self-components, contributing to various autoimmune diseases and …

Post-transcriptional regulation is involved in the regulation of many inflammatory genes. Zinc
finger protein 36 (ZFP36) family proteins are RNA-binding proteins involved in messenger …

Cell identity genes are distinct from other genes with respect to the epigenetic mechanisms
to activate their transcription, eg by super-enhancers and broad H3K4me3 domains …

The adult mammalian heart is thought to be a terminally differentiated organ given the
postmitotic nature of cardiomyocytes. Consequently, the potential for cardiac repair through …

Serine/Arginine splicing factor 1 (SRSF1) is an RNA binding protein abundantly expressed
in most tissues. The pleiotropic functions of SRSF1 exert multiple roles in gene expression …