Traumatic brain injury (TBI) is the most common cause of death and disability in those aged
under 40 years in the UK. Higher rates of morbidity and mortality are seen in low-income …

Intracranial pressure (ICP) monitoring is a staple of neurocritical care. The most commonly
used current methods of monitoring in the acute setting include fluid-based systems …

Background and Objective: Stroke is a leading cause of morbidity and mortality in both
developed and developing countries all over the world. The only drug for ischemic stroke …

There is a growing body of evidencethat indicates that the aging of the brain results from the
decline of energy metabolism. In particular, the neuronal metabolism of glucose declines …

BACKGROUND Intracranial pressure (ICP) is a clinically important variable after severe
traumatic brain injury (TBI) and has been monitored, along with clinical outcome, for over 25 …

Objectives: In severe traumatic brain injury, cerebral perfusion pressure management based
on cerebrovascular pressure reactivity index has the potential to provide a personalized …

Background: Given the increasing worldwide prevalence of chronic kidney disease (CKD), it
is critical to decrease the associated risk of debilitating vascular complications, including …

Introduction Lung protective ventilation (LPV) comprising low tidal volume (VT) and high
positive end-expiratory pressure (PEEP) may compromise cerebral perfusion in acute brain …

Stroke is one of the most devastating pathologies of the early twenty-first century
demonstrating 1-month case-fatality rates ranging from 13 to 35% worldwide. Though the …

New Findings What is the topic of this review? This review provides an up‐to‐date
assessment of the physiology involved with extreme static dry‐land breath holding in trained …