Marine natural products
Covering: 2020 This review covers the literature published in 2020 for marine natural
products (MNPs), with 757 citations (747 for the period January to December 2020) referring …
products (MNPs), with 757 citations (747 for the period January to December 2020) referring …
Wandering beyond small molecules: Peptides as allosteric protein modulators
M Mannes, C Martin, C Menet, S Ballet - Trends in Pharmacological …, 2022 - cell.com
Recent years have seen the rise of allosteric modulation as an innovative approach for drug
design and discovery, efforts which culminated in the development of several clinical …
design and discovery, efforts which culminated in the development of several clinical …
Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae: A Structural Analogue of α-Conotoxins
Elevenins are peptides found in a range of organisms, including arthropods, annelids,
nematodes, and molluscs. They consist of 17 to 19 amino acid residues with a single …
nematodes, and molluscs. They consist of 17 to 19 amino acid residues with a single …
[PDF][PDF] Venom-derived peptides for breaking through the glass ceiling of drug development
Venomous animals are widely distributed taxonomically, represented in both invertebrates
(annelids, arthropods, mollusks, nematodes, cnidarians...) and vertebrates (platypus …
(annelids, arthropods, mollusks, nematodes, cnidarians...) and vertebrates (platypus …
Single-disulfide conopeptide Czon1107, an allosteric antagonist of the human α3β4 nicotinic acetylcholine receptor
Y Ma, Q Cao, M Yang, Y Gao, S Fu, W Du, DJ Adams… - Marine drugs, 2022 - mdpi.com
Conopeptides are peptides in the venom of marine cone snails that are used for capturing
prey or as a defense against predators. A new cysteine-poor conopeptide, Czon1107, has …
prey or as a defense against predators. A new cysteine-poor conopeptide, Czon1107, has …
A short framework-III (mini-M-2) conotoxin from the venom of a vermivorous species, Conus archon, inhibits human neuronal nicotinic acetylcholine receptors
AC Hernández-Sámano, A Falcón, F Zamudio… - Peptides, 2022 - Elsevier
The venoms of Conus snails contain neuroactive peptides named conotoxins (CTXs). Some
CTXs are nicotinic acetylcholine receptor (nAChRs) antagonists. nAChRs modulate the …
CTXs are nicotinic acetylcholine receptor (nAChRs) antagonists. nAChRs modulate the …
Solution structures and thermodynamics of cis-trans X-Pro conformers of a novel single disulfide conopeptide: Structural and conformational studies of conopeptide …
AK Kancherla, SP Sarma - Indian Journal of Biochemistry and …, 2023 - or.niscpr.res.in
Abstract The conopeptide Mo1853 (MW= 1853 Da) consists of 17 residues and a single
disulfide bond. Structural studies using homonuclear solution NMR methods (2D 1 H, 1 H …
disulfide bond. Structural studies using homonuclear solution NMR methods (2D 1 H, 1 H …
[PDF][PDF] Discovery, Design and Synthesis of G Protein Peptidomimetics
M Mannes - 2022 - researchportal.vub.be
The present thesis manuscript concludes my semi-industrial PhD fellowship in both the
fields of peptide synthesis in the Research Group of Organic Chemistry (ORGC), Faculty of …
fields of peptide synthesis in the Research Group of Organic Chemistry (ORGC), Faculty of …