Neisseria meningitidis is a major cause of endemic cases and epidemics of meningitis and
devastating septicemia. Although effective vaccines exist for several serogroups of …

The complement system is an essential player in innate and adaptive immunity. It consists of
three pathways (alternative, classical, and lectin) that initiate either spontaneously …

A unique multicomponent vaccine against serogroup B meningococci incorporates the novel
genome-derived proteins fHbp, NHBA, and NadA that may vary in sequence and level of …

The complement system is an essential component of the innate and acquired immune
system, and consists of a series of proteolytic cascades that are initiated by the presence of …

Neisseria meningitidis remains a leading cause of meningitis and sepsis. This review
provides an update on our understanding of immunity against meningococcal infection …

No broadly effective vaccines are available for prevention of group B meningococcal
disease, which accounts for> 50% of all cases. The group B capsule is an autoantigen and …

Following the impact of the genomics revolution on vaccine research and the development
of reverse vaccinology, it was predicted that another new approach, structure-based antigen …

Vaccination has played a significant role in controlling and eliminating life-threatening
infectious diseases throughout the world, and yet currently licensed vaccines represent only …

Mapping of epitopes recognized by functional monoclonal antibodies (mAbs) is essential for
understanding the nature of immune responses and designing improved vaccines …

The sequence variability of protective antigens is a major challenge to the development of
vaccines. For Neisseria meningitidis, the bacterial pathogen that causes meningitis, the …