Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …

MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

Esophageal squamous-cell carcinoma (ESCC) develops through multistage epithelial
cancer formation, ie, from normal epithelium, low-and high-grade intraepithelial neoplasia to …

Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing
transcription factor that regulates diverse cellular processes such as cell growth …

One of the main engines that drives cellular transformation is the loss of proper control of the
mammalian cell cycle. The cyclin-dependent kinase inhibitor p21 (also known as …

Glioblastoma multiforme (GBM), an aggressive tumor that typically exhibits treatment failure
with high mortality rates, is associated with the presence of cancer stem cells (CSCs) within …

The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

Krüppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with
diverse and essential functions in a multitude of cellular processes, including proliferation …

Aims Neointimal hyperplasia is a common feature of fibro-proliferative vascular disease and
characterizes initial stages of atherosclerosis. Neointimal lesions mainly comprise smooth …

Krüppel-like factors are transcriptional regulators that influence several cellular functions,
including proliferation. Recent studies have shown that one family member, KLF4, can …