[HTML][HTML] Psychosis in Alzheimer disease—mechanisms, genetics and therapeutic opportunities

Z Ismail, B Creese, D Aarsland, HC Kales… - Nature Reviews …, 2022 - nature.com
Psychosis is a common and distressing symptom in people with Alzheimer disease, and few
safe and effective treatments are available. However, new approaches to symptom …

Remote cognitive and behavioral assessment: report of the Alzheimer Society of Canada Task Force on dementia care best practices for COVID‐19

MR Geddes, ME O'Connell, JD Fisk… - Alzheimer's & …, 2020 - Wiley Online Library
Introduction Despite the urgent need for remote neurobehavioral assessment of individuals
with cognitive impairment, guidance is lacking. Our goal is to provide a multi‐dimensional …

[HTML][HTML] Mild behavioral impairment and its relation to tau pathology in preclinical Alzheimer's disease

M Johansson, E Stomrud, PS Insel, A Leuzy… - Translational …, 2021 - nature.com
Mild behavioral impairment (MBI) is suggested as risk marker for neurodegenerative
diseases, such as Alzheimer's disease (AD). Recently, pathologic tau deposition in the brain …

[HTML][HTML] Mild behavioral impairment is associated with atrophy of entorhinal cortex and hippocampus in a memory clinic cohort

V Matuskova, Z Ismail, T Nikolai, H Markova… - Frontiers in aging …, 2021 - frontiersin.org
Objectives Mild behavioral impairment (MBI) is a syndrome describing late-onset persistent
neuropsychiatric symptoms (NPS) in non-demented older adults. Few studies to date have …

Association of locus coeruleus integrity with Braak stage and neuropsychiatric symptom severity in Alzheimer's disease

CM Cassidy, J Therriault, TA Pascoal… - …, 2022 - nature.com
The clinical and pathophysiological correlates of locus coeruleus (LC) degeneration in
Alzheimer's disease (AD) could be clarified using a method to index LC integrity in vivo …

[HTML][HTML] Mild behavioral impairment and subjective cognitive decline predict cognitive and functional decline

Z Ismail, A McGirr, S Gill, S Hu… - Journal of …, 2021 - content.iospress.com
Background: Mild behavioral impairment (MBI) and subjective cognitive decline (SCD) are
dementia risk states, and potentially represent neurobehavioral and neurocognitive …

Validating the mild behavioral impairment checklist in a cognitive clinic: comparisons with the neuropsychiatric inventory questionnaire

S Hu, S Patten, A Charlton, K Fischer… - Journal of geriatric …, 2023 - journals.sagepub.com
Objective To compare the utility of the Mild Behavioral Impairment-Checklist (MBI-C) and
Neuropsychiatric Inventory Questionnaire (NPI-Q) to capture NPS in subjective cognitive …

Neuropsychiatric symptoms and microglial activation in patients with Alzheimer disease

CS Aguzzoli, PCL Ferreira, G Povala… - JAMA Network …, 2023 - jamanetwork.com
Importance Neuropsychiatric symptoms are commonly encountered and are highly
debilitating in patients with Alzheimer disease. Understanding their underpinnings has …

[HTML][HTML] Using machine learning to predict dementia from neuropsychiatric symptom and neuroimaging data

S Gill, P Mouches, S Hu, D Rajashekar… - Journal of …, 2020 - content.iospress.com
Background: Machine learning (ML) is a promising technique for patient-specific prediction
of mild cognitive impairment (MCI) and dementia development. Neuropsychiatric symptoms …

[HTML][HTML] Optimizing detection of Alzheimer's disease in mild cognitive impairment: a 4-year biomarker study of mild behavioral impairment in ADNI and MEMENTO

Z Ismail, R Leon, B Creese, C Ballard, P Robert… - Molecular …, 2023 - Springer
Background Disease-modifying drug use necessitates better Alzheimer disease (AD)
detection. Mild cognitive impairment (MCI) leverages cognitive decline to identify the risk …