Cysteines are amenable to a diverse set of modifications that exhibit critical regulatory
functions over the proteome and thereby control a wide range of cellular processes …

Oxidants produced through endogenous metabolism or encountered in the environment
react directly with reactive sites in biological macromolecules. Many proteins, in particular …

Redox signaling is a fundamental mechanism that controls all major biological processes
partly via protein cysteine oxidations, including S-glutathionylation. Despite over 2000 …

p120-catenin (p120) plays a vital role in regulating cell-cell adhesion at adherens junctions,
interacting with the juxtamembrane domain (JMD) core region of E-cadherin and regulates …

Current methods have limited ability in directly quantifying the extent of glutathionylation on
specific protein-cysteines. In this issue of Cell Chemical Biology, Ahn et al. 1 report G-ICAT …

Protein cysteine is susceptible to diverse oxidations, including disulfide, S-sulfenylation, S-
nitrosylation, and S-glutathionylation, that regulate many biological processes in physiology …