A critically important process in catalysis is the formation of an active catalyst from the
combination of a metal precursor and a ligand, as the efficacy of this reaction governs the …

The use of fungal cultures have been well documented in human history. Although its used
in healthcare, like penicillin and statins, have saved countless of lives, but there is still no …

Covering: 1981–2020 Heck macrocyclization is a logical extension of the award-winning
Mizoroki–Heck reaction. Through covalent linking of two otherwise discrete coupling …

Tetrahydropyridazines are of particular interest for their versatility as intermediates in
organic synthesis and display pharmacological activity in several domains. Here, we …

Introduction: In all living species, pH regulation is a tightly controlled process, with a plethora
of proteins involved in its regulation. These include sodium-proton exchangers, carbonic …

A partial bioinspired as well as the total synthesis of archazolid F, a highly potent V-ATPase
inhibitory, antiproliferative polyketide macrolide, is described. Key features of the synthetic …

Vacuolar type ATPase (V-ATPase) has recently emerged as a promising novel anticancer
target based on extensive in vitro and in vivo studies with archazolids, complex polyketide …

Abstract Palladium (0)‐catalysed hydro‐alkylation or‐alkenylation of alkoxyallenes with N‐
tosylhydrazones gives direct access to conjugated and skipped 1‐alkoxydienes with high …

Full details on the design, development, and successful implementation of suitable synthetic
strategies directed toward the total synthesis of iso-archazolids and archazologs are …

An unprecedented efficient palladium (0)-catalyzed reaction of vinyl oxiranes with N-
tosylhydrazones, affording “skipped” allylic alcohols in total regioselectivity and …