We review the molecular basis of several transcription factors (Eya1, Sox2), including the
three related genes coding basic helix–loop–helix (bHLH; see abbreviations) proteins …

The phenomenon of planar cell polarity is critically required for a myriad of morphogenetic
processes in metazoan and is accurately controlled by several conserved modules. Six …

Our sense of hearing is mediated by sensory hair cells, precisely arranged and highly
specialized cells subdivided into outer hair cells (OHCs) and inner hair cells (IHCs). Light …

Sensorineural hearing loss is the most prevalent sensory deficit in humans. Most cases of
hearing loss are due to the degeneration of key structures of the sensory pathway in the …

Planar polarity describes the organization and orientation of polarized cells or cellular
structures within the plane of an epithelium. The sensory receptor hair cells of the vertebrate …

The gastroesophageal squamocolumnar junction (GE-SCJ) is a critical tissue interface
between the esophagus and stomach, with significant relevance in the pathophysiology of …

Sound is converted by hair cells in the cochlea into electrical signals, which are transmitted
by spiral ganglion neurons (SGNs) and heard by the auditory cortex. G protein-coupled …

Intercellular communication by Wnt proteins governs many essential processes during
development, tissue homeostasis and disease in all metazoans. Many context-dependent …

The WNT5B ligand regulates the non-canonical wingless-related integration site (WNT)–
planar cell polarity (PCP) pathway. However, the detailed mechanism underlying the activity …

We review the molecular basis of three related basic helix–loop–helix (bHLH) genes
(Neurog1, Neurod1, and Atoh1) and upstream regulators Eya1/Six1, Sox2, Pax2, Gata3 …