Mechanisms of protein kinase A anchoring
P Skroblin, S Grossmann, G Schäfer… - International review of …, 2010 - Elsevier
The second messenger cyclic adenosine monophosphate (cAMP), which is produced by
adenylyl cyclases following stimulation of G-protein-coupled receptors, exerts its effect …
adenylyl cyclases following stimulation of G-protein-coupled receptors, exerts its effect …
[HTML][HTML] Networking with AKAPs: context-dependent regulation of anchored enzymes
Abstract A-Kinase Anchoring Proteins (AKAPs) orchestrate and synchronize cellular events
by tethering the cAMP-dependent protein kinase (PKA) and other signaling enzymes to …
by tethering the cAMP-dependent protein kinase (PKA) and other signaling enzymes to …
Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channels
CB Nichols, CF Rossow, MF Navedo… - Circulation …, 2010 - Am Heart Assoc
Rationale: Sympathetic stimulation of the heart increases the force of contraction and rate of
ventricular relaxation by triggering protein kinase (PK) A-dependent phosphorylation of …
ventricular relaxation by triggering protein kinase (PK) A-dependent phosphorylation of …
The C‐terminus of Kv7 channels: a multifunctional module
Y Haitin, B Attali - The Journal of physiology, 2008 - Wiley Online Library
Kv7 channels (KCNQ) represent a family of voltage‐gated K+ channels which plays a
prominent role in brain and cardiac excitability. Their physiological importance is …
prominent role in brain and cardiac excitability. Their physiological importance is …
Neuropathic pain and Kv7 voltage-gated potassium channels: the potential role of Kv7 activators in the treatment of neuropathic pain
A Abd-Elsayed, M Jackson, SL Gu, K Fiala… - Molecular …, 2019 - journals.sagepub.com
Neuropathic pain conditions severely and chronically affect the quality of life in a large
human population, but the pain conditions are not adequately managed due to poor …
human population, but the pain conditions are not adequately managed due to poor …
[HTML][HTML] Cyclic AMP-dependent regulation of Kv7 voltage-gated potassium channels
Voltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological
impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic …
impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic …
Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds
Voltage-gated Kv7 (or KCNQ) channels play a pivotal role in controlling membrane
excitability. Like typical voltage-gated ion channels, Kv7 channels undergo a closed-to-open …
excitability. Like typical voltage-gated ion channels, Kv7 channels undergo a closed-to-open …
Kv7 channels and excitability disorders
F Jones, N Gamper, H Gao - Pharmacology of Potassium Channels, 2021 - Springer
Abstract Kv7. 1-Kv7. 5 (KCNQ1–5) K+ channels are voltage-gated K+ channels with major
roles in neurons, muscle cells and epithelia where they underlie physiologically important …
roles in neurons, muscle cells and epithelia where they underlie physiologically important …
Kv7 channel activation underpins EPAC-dependent relaxations of rat arteries
JB Stott, V Barrese, IA Greenwood - … , thrombosis, and vascular …, 2016 - Am Heart Assoc
Objective—To establish the role of Kv7 channels in EPAC (exchange protein directly
activated by cAMP)-dependent relaxations of the rat vasculature and to investigate whether …
activated by cAMP)-dependent relaxations of the rat vasculature and to investigate whether …
Potential mechanisms of sudden unexpected death in epilepsy
GP Tolstykh, JE Cavazos - Epilepsy & Behavior, 2013 - Elsevier
Sudden unexpected death in epilepsy (SUDEP) accounts for 15% of all deaths in people
with epilepsy and 50% in refractory epilepsy. The underlying mechanisms are not well …
with epilepsy and 50% in refractory epilepsy. The underlying mechanisms are not well …