Nonribosomal peptide synthesis—principles and prospects
RD Süssmuth, A Mainz - Angewandte Chemie International …, 2017 - Wiley Online Library
Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …
assemble numerous peptides with large structural and functional diversity. These peptides …
Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis
RF Little, C Hertweck - Natural Product Reports, 2022 - pubs.rsc.org
Review covering up to mid-2021 The structure of polyketide and non-ribosomal peptide
natural products is strongly influenced by how they are released from their biosynthetic …
natural products is strongly influenced by how they are released from their biosynthetic …
Carboxylic acid reductase enzymes (CARs)
M Winkler - Current opinion in chemical biology, 2018 - Elsevier
Highlights•Carboxylate reductases (CARs) catalyze the selective one step reduction of an
acid to an aldehyde.•The substrate scope of CARs is broad.•CARs have been implemented …
acid to an aldehyde.•The substrate scope of CARs is broad.•CARs have been implemented …
Structural biology of nonribosomal peptide synthetases
The nonribosomal peptide synthetases are modular enzymes that catalyze synthesis of
important peptide products from a variety of standard and non-proteinogenic amino acid …
important peptide products from a variety of standard and non-proteinogenic amino acid …
Kupyaphores are zinc homeostatic metallophores required for colonization of Mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb) endures a combination of metal scarcity and toxicity
throughout the human infection cycle, contributing to complex clinical manifestations …
throughout the human infection cycle, contributing to complex clinical manifestations …
[HTML][HTML] Complex peptide natural products: biosynthetic principles, challenges and opportunities for pathway engineering
SL Wenski, S Thiengmag, EJN Helfrich - Synthetic and systems …, 2022 - Elsevier
Complex peptide natural products exhibit diverse biological functions and a wide range of
physico-chemical properties. As a result, many peptides have entered the clinics for various …
physico-chemical properties. As a result, many peptides have entered the clinics for various …
Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis
Carboxylic acid reductase (CAR) catalyzes the ATP-and NADPH-dependent reduction of
carboxylic acids to the corresponding aldehydes. The enzyme is related to the nonribosomal …
carboxylic acids to the corresponding aldehydes. The enzyme is related to the nonribosomal …
Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases
Covering: up to fall 2022. Nonribosomal peptide synthetases (NRPSs) are a family of
modular, multidomain enzymes that catalyze the biosynthesis of important peptide natural …
modular, multidomain enzymes that catalyze the biosynthesis of important peptide natural …
Engineered polyketides: Synergy between protein and host level engineering
Metabolic engineering efforts toward rewiring metabolism of cells to produce new
compounds often require the utilization of non-native enzymatic machinery that is capable of …
compounds often require the utilization of non-native enzymatic machinery that is capable of …
A peroxisomal disorder of severe intellectual disability, epilepsy, and cataracts due to fatty acyl-CoA reductase 1 deficiency
R Buchert, H Tawamie, C Smith, S Uebe… - The American Journal of …, 2014 - cell.com
Rhizomelic chondrodysplasia punctata (RCDP) is a group of disorders with overlapping
clinical features including rhizomelia, chondrodysplasia punctata, coronal clefts, cervical …
clinical features including rhizomelia, chondrodysplasia punctata, coronal clefts, cervical …