Evidence of significant hearing loss during the early days of use of cisplatin as a
chemotherapeutic agent in cancer patients has stimulated research into the causes and …

Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which
mediate the physiological actions of adenosine. To date, four AR subtypes have been …

The majority of acquired hearing loss, including presbycusis, is caused by irreversible
damage to the sensorineural tissues of the cochlea. This article reviews the intracellular …

Hearing loss is a significant health problem that can result from a variety of exogenous
insults that generate oxidative stress and inflammation. This can produce cellular damage …

Abstract Adenosine kinase (ADK; EC 2.7. 1.20) is an evolutionarily conserved
phosphotransferase that converts the purine ribonucleoside adenosine into 5′-adenosine …

Cisplatin, carboplatin, nedaplatin, and oxaliplatin are widely used in contemporary
oncology; however, their ototoxic and neurotoxic side effects are quite different as discussed …

A significant number of studies support the idea that inflammatory responses are intimately
associated with drug-, noise-and age-related hearing loss (DRHL, NRHL and ARHL) …

Cisplatin is a commonly used antineoplastic agent that produces ototoxicity that is mediated
in part by increasing levels of reactive oxygen species (ROS) via the NOX3 NADPH oxidase …

Apart from the psychotropic compound Δ 9-tetrahydrocannabinol (THC), evidence suggests
that other non-psychotropic phytocannabinoids are also of potential clinical use. This study …

Migraine is the third most prevalent disease on the planet, yet our understanding of its
mechanisms and pathophysiology is surprisingly incomplete. Recent studies have built …