Mammalian mitochondrial translation infidelity leads to oxidative stress–induced cell cycle arrest and cardiomyopathy
WQ Zheng, JH Zhang, ZH Li, X Liu… - Proceedings of the …, 2023 - National Acad Sciences
Proofreading (editing) of mischarged tRNAs by cytoplasmic aminoacyl-tRNA synthetases
(aaRSs), whose impairment causes neurodegeneration and cardiac diseases, is of high …
(aaRSs), whose impairment causes neurodegeneration and cardiac diseases, is of high …
Diversification of aminoacyl-tRNA synthetase activities via genomic duplication
Intricate evolutionary events enabled the emergence of the full set of aminoacyl-tRNA
synthetase (aaRS) families that define the genetic code. The diversification of aaRSs has …
synthetase (aaRS) families that define the genetic code. The diversification of aaRSs has …
Ribosome-mediated biosynthesis of pyridazinone oligomers in vitro
J Lee, JN Coronado, N Cho, J Lim, BM Hosford… - Nature …, 2022 - nature.com
The ribosome is a macromolecular machine that catalyzes the sequence-defined
polymerization of L-α-amino acids into polypeptides. The catalysis of peptide bond formation …
polymerization of L-α-amino acids into polypeptides. The catalysis of peptide bond formation …
Trans-editing by aminoacyl-tRNA synthetase-like editing domains
ABK Nagy, M Bakhtina, K Musier-Forsyth - The Enzymes, 2020 - Elsevier
Aminoacyl-tRNA synthetases (aaRS) are ubiquitous enzymes responsible for aminoacyl-
tRNA (aa-tRNA) synthesis. Correctly formed aa-tRNAs are necessary for proper decoding of …
tRNA (aa-tRNA) synthesis. Correctly formed aa-tRNAs are necessary for proper decoding of …
Protein mistranslation protects bacteria against oxidative stress
Accurate flow of genetic information from DNA to protein requires faithful translation. An
increased level of translational errors (mistranslation) has therefore been widely considered …
increased level of translational errors (mistranslation) has therefore been widely considered …
Molecular basis for t6A modification in human mitochondria
Abstract N 6-Threonylcarbamoyladenosine (t6A) is a universal tRNA modification essential
for translational accuracy and fidelity. In human mitochondria, YrdC synthesises an l …
for translational accuracy and fidelity. In human mitochondria, YrdC synthesises an l …
A human disease-causing point mutation in mitochondrial threonyl-tRNA synthetase induces both structural and functional defects
Mitochondria require all translational components, including aminoacyl-tRNA synthetases
(aaRSs), to complete organelle protein synthesis. Some aaRS mutations cause …
(aaRSs), to complete organelle protein synthesis. Some aaRS mutations cause …
Mechanism of oxidant-induced mistranslation by threonyl-tRNA synthetase
Aminoacyl-tRNA synthetases maintain the fidelity during protein synthesis by selective
activation of cognate amino acids at the aminoacylation site and hydrolysis of misformed …
activation of cognate amino acids at the aminoacylation site and hydrolysis of misformed …
The G3-U70-independent tRNA recognition by human mitochondrial alanyl-tRNA synthetase
QY Zeng, GX Peng, G Li, JB Zhou… - Nucleic Acids …, 2019 - academic.oup.com
Alanyl-tRNA synthetases (AlaRSs) from three domains of life predominantly rely on a single
wobble base pair, G3-U70, of tRNAAla as a major determinant. However, this base pair is …
wobble base pair, G3-U70, of tRNAAla as a major determinant. However, this base pair is …
A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities
TARS and TARS2 encode cytoplasmic and mitochondrial threonyl-tRNA synthetases
(ThrRSs) in mammals, respectively. Interestingly, in higher eukaryotes, a third gene …
(ThrRSs) in mammals, respectively. Interestingly, in higher eukaryotes, a third gene …