Blood-brain barrier (BBB) remains a significant obstacle to drug therapy for brain diseases.
Focused ultrasound (FUS) combined with microbubbles (MBs) can locally and transiently …

Ultrasound mediated drug delivery, a promising therapeutic modality, has evolved
remarkably over the past three decades. Initially designed to enhance contrast in ultrasound …

Messenger RNA (mRNA) medicine has become a new therapeutic approach owing to the
progress in mRNA delivery technology, especially with lipid nanoparticles (LNP). However …

Focused ultrasound (FUS) in combination with systemically injected microbubbles can be
used to non-invasively open the blood-brain barrier (BBB) in targeted regions for a variety of …

Brain diseases including neurological disorders and tumors remain under treated due to the
challenge to access the brain, and blood-brain barrier (BBB) restricting drug delivery which …

Background Focused ultrasound (FUS) is a medical technology that non-invasively
stimulates the brain and has been applied in thermal ablation, blood–brain barrier (BBB) …

Background The persistence of adult hippocampal neurogenesis (AHN) is sharply
decreased in Alzheimer's disease (AD). The neuropathologies of AD include the presence of …

Focused ultrasound (FUS) combined with microbubbles is a non-invasive method for
targeted, reversible disruption of the blood–brain barrier (FUS-BBB opening). This approach …

The blood-brain barrier is the primary obstacle to efficient intracerebral drug delivery.
Focused ultrasound, in conjunction with microbubbles, is a targeted and non-invasive way to …

Background Despite the great potential of FUS-BBB disruption (FUS-BBBD), it is still
controversial whether FUS-BBBD acts as an inducing factor of neuro-inflammation or not …