CD36 is a type 2 cell surface scavenger receptor widely expressed in many immune and
non-immune cells. It functions as both a signaling receptor responding to DAMPs and …

In this brief review we discuss some aspects of the Na+ pump and its roles in mediating the
effects of ouabain and endogenous ouabain (EO): i) in regulating the cytosolic Ca 2+ …

The signaling function of the Na/K-ATPase has been established for 20 years and is widely
accepted in the field, with many excellent reports and reviews not cited here. Even though …

A significant number of patients with coronavirus disease 2019 (COVID-19) develop acute
respiratory distress syndrome (ARDS) that is associated with a poor outcome. The molecular …

In 1972 Neal Bricker presented the “trade-off” hypothesis in which he detailed the role of
physiological adaptation processes in mediating some of the pathophysiology associated …

Cardiotonic steroids are natural compounds that present many physiological and
pharmacological functions. They bind Na+/K+-ATPase (NKA) modifying cellular ion …

Hypertension affects nearly 1.2 billion people worldwide and challenges health systems with
its myriad complications. While the molecular mechanisms underlying this disease are yet to …

Objective: Noncoding RNAs are emerging as important players in gene regulation and
cardiovascular diseases. Their roles in the pathogenesis of atherosclerosis are not fully …

Cardiotonic steroids (CTS), used by certain insects, toads, and rats for protection from
predators, became, thanks to Withering's trailblazing 1785 monograph, the mainstay of heart …

Background and Purpose Cardiac glycosides inhibit Na+/K+‐ATPase and are used to treat
heart failure and arrhythmias. They can induce inflammasome activation and pyroptosis in …