Pathogenic mechanisms underlying idiopathic pulmonary fibrosis
The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …
[HTML][HTML] Fibroblasts: Origins, definitions, and functions in health and disease
Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …
disease by producing complex extracellular matrix and creating signaling niches through …
Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells
JJ Kathiriya, C Wang, M Zhou, A Brumwell… - Nature cell …, 2022 - nature.com
Loss of alveolar type 2 cells (AEC2s) and the ectopic appearance of basal cells in the alveoli
characterize severe lung injuries such as idiopathic pulmonary fibrosis (IPF). Here we …
characterize severe lung injuries such as idiopathic pulmonary fibrosis (IPF). Here we …
Diversity and biology of cancer-associated fibroblasts
G Biffi, DA Tuveson - Physiological reviews, 2020 - journals.physiology.org
Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial
compartment, despite the presence of non-neoplastic stromal components that substantially …
compartment, despite the presence of non-neoplastic stromal components that substantially …
Regulation of epithelial transitional states in murine and human pulmonary fibrosis
F Wang, C Ting, KA Riemondy… - The Journal of …, 2023 - Am Soc Clin Investig
Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease arising from impaired
regeneration of the alveolar epithelium after injury. During regeneration, type 2 alveolar …
regeneration of the alveolar epithelium after injury. During regeneration, type 2 alveolar …
[HTML][HTML] Human lung stem cell-based alveolospheres provide insights into SARS-CoV-2-mediated interferon responses and pneumocyte dysfunction
Coronavirus infection causes diffuse alveolar damage leading to acute respiratory distress
syndrome. The absence of ex vivo models of human alveolar epithelium is hindering an …
syndrome. The absence of ex vivo models of human alveolar epithelium is hindering an …
[HTML][HTML] Transforming growth factor–β in tissue fibrosis
NG Frangogiannis - Journal of Experimental Medicine, 2020 - rupress.org
TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially
restricted generation of bioactive TGF-β from latent stores requires the cooperation of …
restricted generation of bioactive TGF-β from latent stores requires the cooperation of …
Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis
We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung
disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 …
disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 …
Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis
Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …
CD147 as a target for COVID-19 treatment: suggested effects of azithromycin and stem cell engagement
H Ulrich, MM Pillat - Stem cell reviews and reports, 2020 - Springer
The expressive number of deaths and confirmed cases of SARS-CoV-2 call for an urgent
demand of effective and available drugs for COVID-19 treatment. CD147, a receptor on host …
demand of effective and available drugs for COVID-19 treatment. CD147, a receptor on host …