Traditionally, peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a 91 kDa
transcription factor, regulates lipid metabolism and long-chain fatty acid oxidation by …

The build-up of fluid in the peritoneal cavity—ascites—is a hallmark of ovarian cancer, the
most lethal of all gynaecological malignancies. This remarkable fluid, which contains a …

Multiple cancers regulate oxidative stress by activating the transcription factor NRF2 through
mutation of its negative regulator, KEAP1. NRF2 has been studied extensively in KEAP1 …

Platinum-based chemotherapy, including cisplatin, carboplatin, and oxaliplatin, is prescribed
to 10-20% of all cancer patients. Unfortunately, platinum resistance develops in a significant …

Resistance of cancer cells to chemotherapy is the first cause of cancer-associated death.
Thus, new strategies to deal with the evasion of drug response and to improve clinical …

Reprogramming of cancer metabolism is a newly recognized hallmark of malignancy. The
aberrant glucose metabolism is associated with dramatically increased bioenergetics …

Metabolic reprogramming is one of the hallmarks of tumors. Alterations of cellular
metabolism not only contribute to tumor development, but also mediate the resistance of …

Background Platinum based agents—cisplatin and carboplatin in combination with taxanes
are used for the treatment of ovarian cancer (OC) patients. However, the majority of OC …

Cancer cells have enhanced metabolic needs due to their rapid proliferation. Moreover,
throughout their progression from tumor precursors to metastases, cancer cells face …

Aerobic glycolysis is an important metabolic adaptation of cancer cells. There is growing
evidence that oxidative phosphorylation is also an active metabolic pathway in many tumors …