Thalassemic disorders lie on a phenotypic spectrum of clinical severity that depends on the
severity of the globin gene mutation and coinheritance of other genetic determinants. Iron …

The purpose of this article is to set forth our approach to diagnosing and managing the
thalassemias, including β-thalassemia intermedia and β-thalassemia major. The article …

This aim of this statement is to report an expert consensus on the diagnosis and treatment of
cardiac dysfunction in β-thalassemia major (TM). This consensus statement does not cover …

Thalassaemia is one of the most common genetic diseases worldwide, with at least 60 000
severely affected individuals born every year. Individuals originating from tropical and …

The cardiomyopathies are heart muscle diseases of pri-mary or secondary origin. Primary
cardiomyopathies are often of unknown cause, hence their treatment is limited to general …

Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

Iron overload is a common clinical problem, arising from disorders of increased iron
absorption such as hereditary haemochromatosis or thalassaemia intermedia syndromes or …

The β-thalassemia syndromes reflect deficient or absent β-globin synthesis usually owing to
a mutation in the β-globin locus. The relative excess of α-globin results in the formation of …

Patients with β-thalassemia major (TM) and other refractory anemias requiring regular blood
transfusions accumulate iron that damages the liver, endocrine system, and most importantly …

BACKGROUND: The prevalence of primary (hereditary) hemochromatosis and secondary
iron overload (hemosiderosis) is reaching epidemic levels worldwide. Iron-overload leads to …