AD is a neurodegenerative disease, and its frequency is often reported to be higher for
women than men: almost two-thirds of patients with AD are women. One prevailing view is …

Men and women exhibit differences in the development and progression of Alzheimer's
disease (AD). The factors underlying the sex differences in AD are not well understood. This …

Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …

Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous
system (CNS) with unknown etiology. Several factors were hypothesized to be involved in …

Two substrates of insulin-degrading enzyme (IDE), amyloid β-protein (Aβ) and insulin, are
critically important in the pathogenesis of Alzheimer's disease (AD) and type 2 diabetes …

Estrogens influence many physiological processes in mammals, including but not limited to
reproduction, cardiovascular health, bone integrity, cognition, and behavior. Given this …

Emerging data indicate that progesterone has multiple non-reproductive functions in the
central nervous system to regulate cognition, mood, inflammation, mitochondrial function …

Risk for Alzheimer's disease (AD) is associated with age-related loss of sex steroid
hormones in both women and men. In post-menopausal women, the precipitous depletion of …

Estrogens play a crucial physiological function in the brain; however, debates exist
concerning the role of estrogens in Alzheimer's disease (AD). Women during pre-, peri-, or …

Increasing importance is placed on the translational validity of animal models of human
menopause to discern risk vs. benefit for prediction of outcomes after therapeutic …