Liquid biopsies come of age: towards implementation of circulating tumour DNA
Improvements in genomic and molecular methods are expanding the range of potential
applications for circulating tumour DNA (ctDNA), both in a research setting and as a'liquid …
applications for circulating tumour DNA (ctDNA), both in a research setting and as a'liquid …
[HTML][HTML] Noninvasive prenatal screening for fetal aneuploidy, 2016 update: a position statement of the American College of Medical Genetics and Genomics
AR Gregg, BG Skotko, JL Benkendorf, KG Monaghan… - Genetics in …, 2016 - Elsevier
Disclaimer: This statement is designed primarily as an educational resource for clinicians to
help them provide quality medical services. Adherence to this statement is completely …
help them provide quality medical services. Adherence to this statement is completely …
Analysis of circulating tumor DNA to monitor metastatic breast cancer
Background The management of metastatic breast cancer requires monitoring of the tumor
burden to determine the response to treatment, and improved biomarkers are needed …
burden to determine the response to treatment, and improved biomarkers are needed …
Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA
Plasma of cancer patients contains cell-free tumor DNA that carries information on tumor
mutations and tumor burden. Individual mutations have been probed using allele-specific …
mutations and tumor burden. Individual mutations have been probed using allele-specific …
The Digital MIQE Guidelines: Minimum Information for Publication of Quantitative Digital PCR Experiments
JF Huggett, CA Foy, V Benes, K Emslie… - Clinical …, 2013 - academic.oup.com
There is growing interest in digital PCR (dPCR) because technological progress makes it a
practical and increasingly affordable technology. dPCR allows the precise quantification of …
practical and increasingly affordable technology. dPCR allows the precise quantification of …
Application of digital PCR for public health-related water quality monitoring
Digital polymerase chain reaction (dPCR) is emerging as a reliable platform for quantifying
microorganisms in the field of water microbiology. This paper reviews the fundamental …
microorganisms in the field of water microbiology. This paper reviews the fundamental …
Evaluation of a droplet digital polymerase chain reaction format for DNA copy number quantification
Droplet digital polymerase chain reaction (ddPCR) is a new technology that was recently
commercialized to enable the precise quantification of target nucleic acids in a sample …
commercialized to enable the precise quantification of target nucleic acids in a sample …
Considerations for digital PCR as an accurate molecular diagnostic tool
JF Huggett, S Cowen, CA Foy - Clinical chemistry, 2015 - academic.oup.com
Abstract BACKGROUND Digital PCR (dPCR) is an increasingly popular manifestation of
PCR that offers a number of unique advantages when applied to preclinical research …
PCR that offers a number of unique advantages when applied to preclinical research …
Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus
Cell-free fetal DNA is present in the plasma of pregnant women. It consists of short DNA
fragments among primarily maternally derived DNA fragments. We sequenced a maternal …
fragments among primarily maternally derived DNA fragments. We sequenced a maternal …