In the past, most cases of bacterial infection–related glomerulonephritis (IRGN) occurred in
children following streptococcal upper respiratory tract or skin infections and were called …

Despite major advances in understanding genetic predispositions ('first hits'), pathogenic
immune responses, and the mediators of tissue injury in glomerulonephritis (GN), there …

Postinfectious glomerulonephritis is an immunologic response of the kidney to infection,
commonly triggered by streptococci, although many other organisms can cause the …

Postinfectious glomerulonephritis (PIGN) is an immunologically mediated glomerular injury
triggered by an infection. Poststreptococcal glomerulonephritis (PSGN) is a classic example …

Severe group A streptococcal disease including acute poststreptococcal glomerulonephritis
remains a cause of morbidity and mortality in developing countries and among …

Streptococcus pyogenes (group A streptococcus, GAS) is a ubiquitous and important human
bacterial pathogen. This organism possesses several virulence factors to establish infection …

Complement is an integral part of the immune system protecting the host organism against
invasion and proliferation of various microorganisms. It is also involved in the removal of the …

Currently there is no commercial Group A Streptococcus (GAS; S. pyogenes) vaccine
available. The development of safe GAS vaccines is challenging, researchers are …

Acute poststreptococcal GN (APSGN) is the prototype of immune complex GN and is
associated with manifestations of autoimmune reactivity that have been neglected as …

Post-streptococcal glomerulonephritis (PSGN) is primarily associated with preceding Group
A streptococcal skin or throat infections, now mainly observed in economically …