According to the endosymbiotic theory, most of the DNA of the original bacterial
endosymbiont has been lost or transferred to the nucleus, leaving a much smaller (∼ 16 kb …

The intestinal epithelium has one of the highest rates of cellular turnover in a process that is
tightly regulated. As the transit-amplifying progenitors of the intestinal epithelium generate …

A therapeutic strategy that targets multiple proinflammatory factors in inflammatory bowel
disease (IBD) with minimal systemic side effects would be attractive. Here, we develop a …

Biomarker discovery and implementation are at the forefront of the precision medicine
movement. Modern advances in the field of metabolomics afford the opportunity to readily …

Aging and chronic inflammation are independent risk factors for the development of
atherothrombosis and cardiovascular disease. We hypothesized that aging-associated …

Inflammatory bowel diseases are common, complex, immune-mediated conditions with a
sharply rising global prevalence. While major advances since 2000 have provided strong …

The intestinal epithelium represents the most regenerative tissue in the human body, located
in proximity to the dense and functionally diverse microbial milieu of the microbiome …

Abstract The Inflammatory Bowel Diseases (IBD), Ulcerative Colitis (UC) and Crohn's
Disease (CD) are characterised by chronic non-resolving gut mucosal inflammation …

The gastrointestinal microbiome plays a pivotal role in physiological homeostasis of the
intestine as well as in the pathophysiology of diseases including inflammatory bowel …

Mitochondria serve numerous critical cellular functions, rapidly responding to extracellular
stimuli and cellular demands while dynamically communicating with other organelles …