[HTML][HTML] Molecular biology of osteosarcoma
AM Czarnecka, K Synoradzki, W Firlej, E Bartnik… - Cancers, 2020 - mdpi.com
Osteosarcoma (OS) is the most frequent primary bone cancer in children and adolescents
and the third most frequent in adults. Many inherited germline mutations are responsible for …
and the third most frequent in adults. Many inherited germline mutations are responsible for …
[HTML][HTML] Current status and prospects of targeted therapy for osteosarcoma
Z Hu, S Wen, Z Huo, Q Wang, J Zhao, Z Wang, Y Chen… - Cells, 2022 - mdpi.com
Osteosarcoma (OS) is a highly malignant tumor occurring in bone tissue with a high
propensity to metastasize, and its underlying mechanisms remain largely elusive. The OS …
propensity to metastasize, and its underlying mechanisms remain largely elusive. The OS …
Payload-delivering engineered γδ T cells display enhanced cytotoxicity, persistence, and efficacy in preclinical models of osteosarcoma
D Fowler, M Barisa, A Southern, C Nattress… - Science Translational …, 2024 - science.org
T cell–based cancer immunotherapy has typically relied on membrane-bound cytotoxicity
enhancers such as chimeric antigen receptors expressed in autologous αβ T cells. These …
enhancers such as chimeric antigen receptors expressed in autologous αβ T cells. These …
[HTML][HTML] Chondrosarcoma resistance to radiation therapy: Origins and potential therapeutic solutions
A Gilbert, M Tudor, J Montanari, K Commenchail… - Cancers, 2023 - mdpi.com
Simple Summary This review article aims in describing the origins of chondrosarcoma
radiation-resistance and proposes several potential solutions in order to improve the …
radiation-resistance and proposes several potential solutions in order to improve the …
Emerging next-generation sequencing-based discoveries for targeted osteosarcoma therapy
J Zhao, DC Dean, FJ Hornicek, X Yu, Z Duan - Cancer letters, 2020 - Elsevier
Osteosarcoma (OS) is the most common primary bone malignancy and is frequently lethal
via metastasis to the lung. While surgical techniques and adjuvant chemotherapies have …
via metastasis to the lung. While surgical techniques and adjuvant chemotherapies have …
[HTML][HTML] MMP14 in sarcoma: a regulator of tumor microenvironment communication in connective tissues
Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The
expression and function of the membrane-type matrix metalloproteinase MMP14 is closely …
expression and function of the membrane-type matrix metalloproteinase MMP14 is closely …
[HTML][HTML] Dog breeds and conformations predisposed to osteosarcoma in the UK: a VetCompass study
DG O'Neill, GL Edmunds, J Urquhart-Gilmore… - Canine Medicine and …, 2023 - Springer
Background Osteosarcoma is a malignant bone neoplasia that has high welfare
consequences for affected dogs. Awareness of breed and canine conformational risk factors …
consequences for affected dogs. Awareness of breed and canine conformational risk factors …
[HTML][HTML] The YAP/TEAD axis as a new therapeutic target in osteosarcoma: effect of verteporfin and CA3 on primary tumor growth
S Morice, M Mullard, R Brion, M Dupuy, S Renault… - Cancers, 2020 - mdpi.com
Simple Summary The low survival rate of osteosarcoma (OS) patients underlines the
urgency of developing new therapeutic strategies for this disease. In recent years, the …
urgency of developing new therapeutic strategies for this disease. In recent years, the …
[HTML][HTML] Targeting the Wnt/β-catenin pathway in human osteosarcoma cells
F Fang, A VanCleave, R Helmuth, H Torres, K Rickel… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Aberrant activation of Wnt signaling has been implicated in human osteosarcoma, which
may provide a genetic vulnerability that can be targeted in osteosarcoma treatment. To test …
may provide a genetic vulnerability that can be targeted in osteosarcoma treatment. To test …