Bioavailability and risk assessment of orally ingested polycyclic aromatic hydrocarbons

A Ramesh, SA Walker, DB Hood… - … journal of toxicology, 2004 - journals.sagepub.com
Polycyclic aromatic hydrocarbons (PAHs) are a family of toxicants that are ubiquitous in the
environment. These contaminants generate considerable interest, because some of them …

Polycyclic aromatic hydrocarbons and digestive tract cancers: a perspective

DL Diggs, AC Huderson, KL Harris… - … science and health …, 2011 - Taylor & Francis
Cancers of the colon are most common in the Western world. In majority of these cases,
there is no familial history and sporadic gene damage seems to play an important role in the …

Gap junctions as targets for cancer chemoprevention and chemotherapy

JE Trosko, RJ Ruch - Current Drug Targets, 2002 - ingentaconnect.com
The development of the most efficacious strategy for the prevention and treatment of cancers
is based on understanding the underlying mechanisms of carcinogenesis. This includes the …

Pharmacodynamic activity of drugs and ecotoxicology—can the two be connected?

JP Seiler - Toxicology Letters, 2002 - Elsevier
Therapeutic agents, active substances as well as metabolites, have been detected in the
environment, notably in the aquatic compartment. Such contamination may induce adverse …

Commentary: is the concept of “tumor promotion” a useful paradigm?

JE Trosko - … Carcinogenesis: Published in cooperation with the …, 2001 - Wiley Online Library
Since the demonstration of the multistage nature of carcinogenesis in experimental work on
mouse skin carcinogenesis (and subsequently on various other organ systems in other …

Epigenetics and environmental exposures

RA Stein - J Epidemiol Community Health, 2012 - jech.bmj.com
It is becoming increasingly apparent that genetic factors are inadequate to fully explain
many processes that shape development and disease. For example, monozygotic twin pairs …

Cell population dynamics (apoptosis, mitosis, and cell–cell communication) during disruption of homeostasis

MR Wilson, TW Close, JE Trosko - Experimental cell research, 2000 - Elsevier
The sequence of events involved in maintenance of homeostasis must encompass
mechanisms within single cells as well as interactions between cells within a population. To …

Polar compounds dominate in vitro effects of sediment extracts

U Lübcke-von Varel, M Machala… - … science & technology, 2011 - ACS Publications
Sediment extracts from three polluted sites of the river Elbe basin were fractionated using a
novel online fractionation procedure. Resulting fractions were screened for mutagenic, aryl …

The emperor wears no clothes in the field of carcinogen risk assessment: ignored concepts in cancer risk assessment

JE Trosko, BL Upham - Mutagenesis, 2005 - academic.oup.com
The following is a position paper challenging the paradigm that 'carcinogen= mutagen', and
that the current rodent bioassay to predict risks to human cancers is relevant and useful …

Inhibition of gap-junctional intercellular communication by environmentally occurring polycyclic aromatic hydrocarbons

L Bláha, P Kapplová, J Vondráček… - Toxicological …, 2002 - academic.oup.com
Polycyclic aromatic hydrocarbons (PAHs) are a broad class of ubiquitous environmental
pollutants with known or suspected carcinogenic properties. Tumor promotion is a cell …