The serotonergic system extends throughout the central nervous system (CNS) and the
gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a …

Modern optogenetics can be tuned to evoke activity that corresponds to naturally occurring
local or global activity in timing, magnitude or individual-cell patterning. This outcome has …

Anxiety-like behaviors in mice include social avoidance and avoidance of bright spaces.
Whether these features are distinctly regulated is unclear. We demonstrate that in mice …

Depression is a polygenic and highly complex psychiatric disorder that remains a major
burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) …

Serotonin neurons of the dorsal and median raphe nuclei (DR, MR) collectively innervate
the entire forebrain and midbrain, modulating diverse physiology and behavior. To gain a …

The serotonin system modulates a wide variety of emotional behaviors and states, including
reward processing, anxiety, and social interaction. To reveal the underlying patterns of …

Attention is critical to high-level cognition and attention deficits are a hallmark of neurologic
and neuropsychiatric disorders. Although years of research indicates that distinct …

Gut microbiome diversity has been strongly associated with mood-relating behaviours,
including major depressive disorder (MDD). This association stems from the recently …

The dorsal raphe (DR) constitutes a major serotonergic input to the forebrain and modulates
diverse functions and brain states, including mood, anxiety, and sensory and motor …

Naturalistic observations show that decisions to avoid or escape predators occur at different
spatiotemporal scales and that they are supported by different computations and neural …