This comprehensive review, covering 2021–2023, explores the multifaceted chemical and
pharmacological potential of coumarins, emphasizing their significance as versatile natural …

Tyrosinase plays crucial roles in mediating the production of melanin pigment; thus, its
inhibitors could be useful in preventing melanin-related diseases. To find potential …

Paeonol, as one effective tyrosinase inhibitor, had been used as food preservative and
clinical medication for skin disorders. In this study, the inhibition mechanism and binding …

Piperazine is a privileged moiety that is a structural part of many clinical drugs. Piperazine-
based scaffolds have attracted the attention of pharmaceutical and medicinal scientists to …

Ten 2-mercaptobenzimidazole (2-MBI) analogs were synthesized as potential tyrosinase
inhibitors because mercapto-containing compounds can bind to copper ions at the active …

Premature skin-aging is a disorder in human skin tissue caused by the effects of
environmental factors. It is important to prevent and treat this disorder using natural …

Tyrosinase is an important rate-limiting enzyme in melanin biosynthesis. To find potential
tyrosinase inhibitors with anti-melanogenic activity, a series of indole-thiazolidine-2, 4-dione …

Tyrosinase is a biological macromolecule closely related to browning of fruit and vegetables,
melanin production, and tyrosinase inhibitors are usually used to prevent browning and …

Climate change is affecting all regions of the world, and the Mediterranean region is one of
the most affected. Plants accumulate secondary metabolites as an adaptive response to …

Background: Melanogenesis is the process of forming melanin pigment initiated by the
amino acid L-tyrosine; the main enzyme is tyrosinase. Tyrosinase acts as a catalyst for the …