Integrated MRI-guided radiotherapy—opportunities and challenges

PJ Keall, C Brighi, C Glide-Hurst, G Liney… - Nature Reviews …, 2022 - nature.com
MRI can help to categorize tissues as malignant or non-malignant both anatomically and
functionally, with a high level of spatial and temporal resolution. This non-invasive imaging …

Radiation oncology in the era of precision medicine

M Baumann, M Krause, J Overgaard, J Debus… - Nature Reviews …, 2016 - nature.com
Technological advances and clinical research over the past few decades have given
radiation oncologists the capability to personalize treatments for accurate delivery of …

CSC radioresistance: a therapeutic challenge to improve radiotherapy effectiveness in cancer

MA Olivares-Urbano, C Griñán-Lisón, JA Marchal… - Cells, 2020 - mdpi.com
Radiotherapy (RT) is a modality of oncologic treatment that can be used to treat
approximately 50% of all cancer patients either alone or in combination with other treatment …

Carbon ion radiobiology

W Tinganelli, M Durante - Cancers, 2020 - mdpi.com
Simple Summary Radiotherapy with carbon ions has been used for over 20 years in Asia
and Europe and is now planned in the USA. The physics advantages of carbon ions …

Magnetic nanoparticles for medical applications: Updated review

GG Flores-Rojas, F López-Saucedo, R Vera-Graziano… - Macromol, 2022 - mdpi.com
Magnetic nanoparticles (MNPs) represent an advanced tool in the medical field because
they can be modified according to biomedical approaches and guided by an external …

Charged-particle therapy in cancer: clinical uses and future perspectives

M Durante, R Orecchia, JS Loeffler - Nature Reviews Clinical Oncology, 2017 - nature.com
Radiotherapy with high-energy charged particles has become an attractive therapeutic
option for patients with several tumour types because this approach better spares healthy …

Biological response of cancer cells to radiation treatment

R Baskar, J Dai, N Wenlong, R Yeo… - Frontiers in molecular …, 2014 - frontiersin.org
Cancer is a class of diseases characterized by uncontrolled cell growth and has the ability to
spread or metastasize throughout the body. In recent years, remarkable progress has been …

Physics and biomedical challenges of cancer therapy with accelerated heavy ions

M Durante, J Debus, JS Loeffler - Nature Reviews Physics, 2021 - nature.com
Radiotherapy should have low toxicity in the entrance channel (normal tissue) and be very
effective in cell killing in the target region (tumour). In this regard, ions heavier than protons …

Carbon ion radiotherapy in Japan: an assessment of 20 years of clinical experience

T Kamada, H Tsujii, EA Blakely, J Debus… - The Lancet …, 2015 - thelancet.com
Charged particle therapy is generally regarded as cutting-edge technology in oncology.
Many proton therapy centres are active in the USA, Europe, and Asia, but only a few centres …

The role of cancer stem cells in radiation resistance

CR Arnold, J Mangesius, II Skvortsova… - Frontiers in …, 2020 - frontiersin.org
Cancer stem cells (CSC) are a distinct subpopulation within a tumor. They are able to self-
renew and differentiate and possess a high capability to repair DNA damage, exhibit low …