Hepatic inflammatory responses in liver fibrosis
L Hammerich, F Tacke - Nature Reviews Gastroenterology & …, 2023 - nature.com
Chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) or viral hepatitis are
characterized by persistent inflammation and subsequent liver fibrosis. Liver fibrosis critically …
characterized by persistent inflammation and subsequent liver fibrosis. Liver fibrosis critically …
An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH
Successful development of treatments for non-alcoholic fatty liver disease and its
progressive form, non-alcoholic steatohepatitis (NASH), has been challenging. Because …
progressive form, non-alcoholic steatohepatitis (NASH), has been challenging. Because …
Alcohol-associated liver disease
B Mackowiak, Y Fu, L Maccioni… - The Journal of Clinical …, 2024 - Am Soc Clin Investig
Alcohol-associated liver disease (ALD) is a major cause of chronic liver disease worldwide,
and comprises a spectrum of several different disorders, including simple steatosis …
and comprises a spectrum of several different disorders, including simple steatosis …
Kupffer cell–like Syncytia replenish resident macrophage function in the Fibrotic liver
Kupffer cells (KCs) are localized in liver sinusoids but extend pseudopods to parenchymal
cells to maintain their identity and serve as the body's central bacterial filter. Liver cirrhosis …
cells to maintain their identity and serve as the body's central bacterial filter. Liver cirrhosis …
[HTML][HTML] Invited review liver fibrosis in NAFLD/NASH: From pathophysiology towards diagnostic and therapeutic strategies
Liver fibrosis, as an excess deposition of extracellular matrix (ECM) components, results
from chronic liver injury as well as persistent activation of inflammatory response and of …
from chronic liver injury as well as persistent activation of inflammatory response and of …
Monocyte-derived macrophages orchestrate multiple cell-type interactions to repair necrotic liver lesions in disease models
The liver can fully regenerate after partial resection, and its underlying mechanisms have
been extensively studied. The liver can also rapidly regenerate after injury, with most studies …
been extensively studied. The liver can also rapidly regenerate after injury, with most studies …
The contradictory roles of macrophages in non-alcoholic fatty liver disease and primary liver cancer—Challenges and opportunities
Chronic liver diseases from varying etiologies generally lead to liver fibrosis and cirrhosis.
Among them, non-alcoholic fatty liver disease (NAFLD) affects roughly one-quarter of the …
Among them, non-alcoholic fatty liver disease (NAFLD) affects roughly one-quarter of the …
Metabolic reprogramming in liver fibrosis
Chronic liver diseases, primarily metabolic dysfunction-associated steatotic liver disease
(MASLD), harmful use of alcohol, or viral hepatitis, may result in liver fibrosis, cirrhosis, and …
(MASLD), harmful use of alcohol, or viral hepatitis, may result in liver fibrosis, cirrhosis, and …
[HTML][HTML] Single-cell, single-nucleus, and spatial transcriptomics characterization of the immunological landscape in the healthy and PSC human liver
Background & Aims Primary sclerosing cholangitis (PSC) is an immune-mediated
cholestatic liver disease for which there is an unmet need to understand the cellular …
cholestatic liver disease for which there is an unmet need to understand the cellular …
Spatial genomics: mapping human steatotic liver disease
KP Matchett, J Paris, SA Teichmann… - Nature Reviews …, 2024 - nature.com
Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as non-
alcoholic fatty liver disease) is a leading cause of chronic liver disease worldwide. MASLD …
alcoholic fatty liver disease) is a leading cause of chronic liver disease worldwide. MASLD …