During the previous decade, a new array of analytical methodologies and technologies were
introduced related to the analysis of microbial, plant and animal metabolomes (complete …

Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which
leads to elevated levels of phosphocholine and glycerophosphocholine in all types of …

The gut microbiome has been shown to regulate the development and functions of the
enteric and central nervous systems. Its involvement in the regulation of behavior has …

Noninvasive imaging at the molecular level is an emerging field in biomedical research. This
paper introduces a new technology synergizing two leading imaging methodologies …

A comprehensive comparative study of metabolite quantification from the human brain was
performed on the same 10 subjects at 4T and 7T using MR scanners with identical consoles …

At present, there are few means to track symptomatic stages of CNS aging. Thus, although
metabolic changes are implicated in mtDNA mutation-driven aging, the manifestations …

Magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) allow the
chemical analysis of physiological processes in vivo and provide powerful tools in the life …

Proton NMR spectroscopy is emerging from translational and preclinical neuroscience
research as an important tool for evidence based diagnosis and therapy monitoring. It …

It is well established that lactate can be used as an energy substrate by the brain by
conversion to pyruvate and a subsequent oxidation in the mitochondria. Knowing the need …

Multimodal imaging is now well-established in routine clinical practice. Especially in the field
of nuclear medicine, new positron emission tomography (PET) installations comprise almost …