A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …

Human zona pellucida (ZP) matrix is composed of four glycoproteins designated as ZP
glycoprotein-1 (ZP1),-2 (ZP2),-3 (ZP3), and-4 (ZP4). Mutations in the genes encoding human …

BACKGROUND Our previous studies have demonstrated the cystic fibrosis transmembrane
conductance regulator (CFTR) is important for capacitation and male fertility in mouse and …

Acrosome reaction is crucial to the penetration of spermatozoa through the zona pellucida
(ZP). Glycosylation of ZP glycoproteins is important in spermatozoa-ZP interaction. Human …

Heat shock protein 90 plays critical roles in client protein maturation, signal transduction,
protein folding and degradation, and morphological evolution; however, its function in …

The zona pellucida (ZP), a glycoproteinaceous matrix surrounding the mammalian oocyte
plays an important role in species-specific sperm–egg binding, induction of acrosome …

For successful fertilization mammalian spermatozoa must undergo the acrosome reaction
(AR), an exocytotic event that allows this cell to penetrate the outer layer of the oocyte, the …

Background Selection of the best oocyte for subsequent steps of fertilization and embryo
transfer was shown to be the crucial step in human infertility treatment procedure. Oocyte …

Background The human egg coat, zona pellucida (ZP), is composed of four glycoproteins
designated as zona pellucida glycoprotein-1 (ZP1),-2 (ZP2),-3 (ZP3) and-4 (ZP4) …

STUDY QUESTION Does adjudin disrupt chloride ion (Cl−) ion transport function in human
sperm and impede sperm capacitation and fertilizing ability in vitro? SUMMARY ANSWER In …