The technology, opportunities and challenges of synthetic biological intelligence

BJ Kagan, C Gyngell, T Lysaght, VM Cole… - Biotechnology …, 2023 - Elsevier
Integrating neural cultures developed through synthetic biology methods with digital
computing has enabled the early development of Synthetic Biological Intelligence (SBI) …

Human iPSC-derived neural models for studying Alzheimer's disease: from neural stem cells to cerebral organoids

M Barak, V Fedorova, V Pospisilova, J Raska… - Stem Cell Reviews and …, 2022 - Springer
During the past two decades, induced pluripotent stem cells (iPSCs) have been widely used
to study mechanisms of human neural development, disease modeling, and drug discovery …

Neuronal enhancers are hotspots for DNA single-strand break repair

W Wu, SE Hill, WJ Nathan, J Paiano, E Callen, D Wang… - Nature, 2021 - nature.com
Defects in DNA repair frequently lead to neurodevelopmental and neurodegenerative
diseases, underscoring the particular importance of DNA repair in long-lived post-mitotic …

The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency

A Bertero, S Brown, P Madrigal, A Osnato, D Ortmann… - Nature, 2018 - nature.com
The TGFβ pathway has essential roles in embryonic development, organ homeostasis,
tissue repair and disease,. These diverse effects are mediated through the intracellular …

Single-cell atlas of human liver development reveals pathways directing hepatic cell fates

BT Wesley, ADB Ross, D Muraro, Z Miao, S Saxton… - Nature Cell …, 2022 - nature.com
The liver has been studied extensively due to the broad number of diseases affecting its vital
functions. However, therapeutic advances have been hampered by the lack of knowledge …

Functional neurological restoration of amputated peripheral nerve using biohybrid regenerative bioelectronics

AE Rochford, A Carnicer-Lombarte, M Kawan, A Jin… - Science …, 2023 - science.org
The development of neural interfaces with superior biocompatibility and improved tissue
integration is vital for treating and restoring neurological functions in the nervous system. A …

Essential steps in bioprinting: From pre-to post-bioprinting

P Datta, A Barui, Y Wu, V Ozbolat, KK Moncal… - Biotechnology …, 2018 - Elsevier
An increasing demand for directed assembly of biomaterials has inspired the development
of bioprinting, which facilitates the assembling of both cellular and acellular inks into well …

Cholesterol determines the cytosolic entry and seeded aggregation of tau

BJ Tuck, LVC Miller, T Katsinelos, AE Smith, EL Wilson… - Cell Reports, 2022 - cell.com
Assemblies of tau can transit between neurons, seeding aggregation in a prion-like manner.
To accomplish this, tau must cross cell-limiting membranes, a process that is poorly …

[HTML][HTML] A simple and robust serum-free media for the proliferation of muscle cells

S Skrivergaard, JF Young, N Sahebekhtiari… - Food Research …, 2023 - Elsevier
Cultivated meat production requires an efficient, robust and highly optimized serum-free cell
culture media for the needed upscaling of muscle cell expansion. Existing formulations of …

Lipid‐bilayer‐supported 3D printing of human cerebral cortex cells reveals developmental interactions

L Zhou, AC Wolfes, Y Li, DCW Chan, H Ko… - Advanced …, 2020 - Wiley Online Library
Current understanding of human brain development is rudimentary due to suboptimal in
vitro and animal models. In particular, how initial cell positions impact subsequent human …