The technology, opportunities and challenges of synthetic biological intelligence
Integrating neural cultures developed through synthetic biology methods with digital
computing has enabled the early development of Synthetic Biological Intelligence (SBI) …
computing has enabled the early development of Synthetic Biological Intelligence (SBI) …
Human iPSC-derived neural models for studying Alzheimer's disease: from neural stem cells to cerebral organoids
M Barak, V Fedorova, V Pospisilova, J Raska… - Stem Cell Reviews and …, 2022 - Springer
During the past two decades, induced pluripotent stem cells (iPSCs) have been widely used
to study mechanisms of human neural development, disease modeling, and drug discovery …
to study mechanisms of human neural development, disease modeling, and drug discovery …
Neuronal enhancers are hotspots for DNA single-strand break repair
Defects in DNA repair frequently lead to neurodevelopmental and neurodegenerative
diseases, underscoring the particular importance of DNA repair in long-lived post-mitotic …
diseases, underscoring the particular importance of DNA repair in long-lived post-mitotic …
The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency
The TGFβ pathway has essential roles in embryonic development, organ homeostasis,
tissue repair and disease,. These diverse effects are mediated through the intracellular …
tissue repair and disease,. These diverse effects are mediated through the intracellular …
Single-cell atlas of human liver development reveals pathways directing hepatic cell fates
The liver has been studied extensively due to the broad number of diseases affecting its vital
functions. However, therapeutic advances have been hampered by the lack of knowledge …
functions. However, therapeutic advances have been hampered by the lack of knowledge …
Functional neurological restoration of amputated peripheral nerve using biohybrid regenerative bioelectronics
The development of neural interfaces with superior biocompatibility and improved tissue
integration is vital for treating and restoring neurological functions in the nervous system. A …
integration is vital for treating and restoring neurological functions in the nervous system. A …
Essential steps in bioprinting: From pre-to post-bioprinting
An increasing demand for directed assembly of biomaterials has inspired the development
of bioprinting, which facilitates the assembling of both cellular and acellular inks into well …
of bioprinting, which facilitates the assembling of both cellular and acellular inks into well …
Cholesterol determines the cytosolic entry and seeded aggregation of tau
Assemblies of tau can transit between neurons, seeding aggregation in a prion-like manner.
To accomplish this, tau must cross cell-limiting membranes, a process that is poorly …
To accomplish this, tau must cross cell-limiting membranes, a process that is poorly …
[HTML][HTML] A simple and robust serum-free media for the proliferation of muscle cells
S Skrivergaard, JF Young, N Sahebekhtiari… - Food Research …, 2023 - Elsevier
Cultivated meat production requires an efficient, robust and highly optimized serum-free cell
culture media for the needed upscaling of muscle cell expansion. Existing formulations of …
culture media for the needed upscaling of muscle cell expansion. Existing formulations of …
Lipid‐bilayer‐supported 3D printing of human cerebral cortex cells reveals developmental interactions
Current understanding of human brain development is rudimentary due to suboptimal in
vitro and animal models. In particular, how initial cell positions impact subsequent human …
vitro and animal models. In particular, how initial cell positions impact subsequent human …