Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …

Coccidioidomycosis, colloquially known as Valley Fever, is an invasive dimorphic fungal
infection caused by Coccidioides immitis and C. posadasii. The fungi are found in the arid …

It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

Since their discovery in patients with autosomal dominant (AD) chronic mucocutaneous
candidiasis (CMC) in 2011, heterozygous STAT1 gain-of-function (GOF) mutations have …

Heterozygous gain-of-function (GOF) mutations in STAT1 in patients with chronic
mucocutaneous candidiasis (CMC) and hypothyroidism were discovered in 2011. CMC is …

Non-tuberculous mycobacteria cause a broad range of clinical disorders, from cutaneous
infections, such as cervical or intrathoracic lymphadenitis in children, to disseminated …

Candida albicans is a dimorphic fungus responsible for chronic mucocutaneous and
systemic infections. Mucocutaneous immunity to C. albicans requires T helper 17 (Th17) cell …

Patients with inborn errors of interleukin-17F (IL-17F) or IL-17RA display chronic
mucocutaneous candidiasis (CMC). We report a biallelic missense mutation (T536I) in the …

Coccidioidomycosis is the endemic mycosis caused by the fungal pathogens Coccidioides
immitis and C. posadasii. This review is a summary of the recent advances that have been …

CMC, invasive candidiasis, invasive aspergillosis, deep dermatophytosis, pneumocystosis,
and endemic mycoses can all be caused by PIDs. Each type of infection is highly suggestive …