The mitogen-activated protein kinase (MAPK) cascade is one of the most important of the
intracellular signaling pathways that play a crucial role in cell proliferation, cell differentiation …

Mitogen-activated protein kinase (MAPK) is a family of Ser/Thr protein kinases that are
widely distributed in eukaryotic cells. Studies in the last decade revealed that MAPK …

The present review aims to analyse (i) the molecular, biochemical and cellular changes that
accompany oocyte and sperm ageing in any of the internal or external environments where …

Fertile offspring from somatic cell nuclear transfer (SCNT) is the goal of most cloning
laboratories. For this process to be successful, a number of events must occur correctly. First …

To clone a pig from somatic cells, we first validated an electrical activation method for use on
ovulated oocytes. We then evaluated delayed versus simultaneous activation (DA vs. SA) …

Our previous studies have shown that oocytes collected from prepubertal calves lack
developmental competence. The overall objective of this study was to assess causes by …

BACKGROUND: The senescence-accelerated mouse (SAM) has been shown to exhibit
ageing-associated mitochondrial dysfunction and oxidative stress, and early decline in …

Normal fertility in females depends upon precise regulation of oocyte meiosis. Oocytes are
arrested in prophase I of meiosis until just before ovulation, when meiosis, or maturation, is …

Strontium has been successfully used to induce activation of mouse oocytes in nuclear
transfer and other experiments, but the optimum treatment conditions have not been studied …

STUDY QUESTION What is the potential impact of follicular fluid (FF) from infertile women
with mild endometriosis (ME) on oocyte quality, especially on nuclear maturation and the …