Recent developments of chalcones as potential antibacterial agents in medicinal chemistry
W Dan, J Dai - European journal of medicinal chemistry, 2020 - Elsevier
Chalcones, containing an α, β-unsaturated ketone fragment, are an important
pharmacologically active agents because of their diverse mechanisms. This review provides …
pharmacologically active agents because of their diverse mechanisms. This review provides …
Chalcones and their therapeutic targets for the management of diabetes: structural and pharmacological perspectives
Diabetes Mellitus (DM) is the fastest growing metabolic disorder affecting about 387 million
people across the globe and is estimated to affect 592 million people by year 2030. The …
people across the globe and is estimated to affect 592 million people by year 2030. The …
[HTML][HTML] Diverse molecular targets for chalcones with varied bioactivities
B Zhou, C Xing - Medicinal chemistry, 2015 - ncbi.nlm.nih.gov
Natural or synthetic chalcones with different substituents have revealed a variety of
biological activities that may benefit human health. The underlying mechanisms of action …
biological activities that may benefit human health. The underlying mechanisms of action …
Chalcone scaffolds as anti-infective agents: Structural and molecular target perspectives
In recent years, widespread outbreak of numerous infectious diseases across the globe has
created havoc among the population. Particularly, the inhabitants of tropical and sub-tropical …
created havoc among the population. Particularly, the inhabitants of tropical and sub-tropical …
Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system
Mycobacterium tuberculosis PtpA, a secreted tyrosine phosphatase essential for
tuberculosis pathogenicity, could be an ideal target for a drug against tuberculosis, but its …
tuberculosis pathogenicity, could be an ideal target for a drug against tuberculosis, but its …
Therapeutic potential of chalcones as cardiovascular agents
DK Mahapatra, SK Bharti - Life sciences, 2016 - Elsevier
Cardiovascular diseases are the leading cause of death affecting 17.3 million people across
the globe and are estimated to affect 23.3 million people by year 2030. In recent years …
the globe and are estimated to affect 23.3 million people by year 2030. In recent years …
Acid catalyzed one-pot approach towards the synthesis of curcuminoid systems: unsymmetrical diarylidene cycloalkanones, exploration of their single crystals, optical …
In the present study crystalline unsymmetrical diarylidene ketone derivatives BNTP and
BDBC have been prepared by two sequential acid catalyzed aldol condensation reactions in …
BDBC have been prepared by two sequential acid catalyzed aldol condensation reactions in …
Mycobacterium tuberculosis Serine/Threonine Protein Kinases
Signal transduction is an essential activity of all living cells. Broadly defined, signal
transduction is the sensing of a signal or input and its conversion into an output or response …
transduction is the sensing of a signal or input and its conversion into an output or response …
Facile preparation, characterization, SC-XRD and DFT/DTDFT study of diversely functionalized unsymmetrical bis-aryl-α, β-unsaturated ketone derivatives
The current research work is about the synthesis of diversely functionalized unsymmetrical
mono-carbonyl curcuminoids:(1E, 4E)-1-(2-methoxy-4-nitrophenyl)-5-(4-methoxyphenyl)-2 …
mono-carbonyl curcuminoids:(1E, 4E)-1-(2-methoxy-4-nitrophenyl)-5-(4-methoxyphenyl)-2 …
Planejamento de fármacos, biotecnologia e química medicinal: aplicações em doenças infecciosas
Estratégias modernas de planejamento de fármacos se fundamentam no conhecimento da
fisiopatologia das doenças, no estudo de vias bioquímicas e na seleção de alvos …
fisiopatologia das doenças, no estudo de vias bioquímicas e na seleção de alvos …