Highlights•Ideal mass spectrometer for MALDI MSI would satisfy the '4S-criteria for
performance'(speed, specificity, spatial resolution and sensitivity).•Quantification MALDI MSI …

Compared with conventional optical microscopy techniques, mass spectrometry imaging
(MSI) or imaging mass spectrometry (IMS) is a powerful, label-free analytical technique …

Spatially resolved tissue lipidomics is essential for accurate intraoperative and postoperative
cancer diagnosis by revealing molecular information in the tumor microenvironment. Matrix …

Matrix-assisted laser desorption/ionization (MALDI) is one of the most successful “soft”
ionization methods in the field of mass spectrometry and enables the analysis of a broad …

There is an increasing appreciation that every cell, even of the same type, is different. This
complexity, when additionally combined with the variety of different cell types in tissue, is …

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a fast-
growing technique for visualization of the spatial distribution of the small molecular and …

Multimodal imaging is a powerful strategy for combining information from multiple images. It
involves several fields in the acquisition, processing and interpretation of images. As …

The mainstream of lipidomics involves mass spectrometry-based, systematic, and large-
scale studies of the structure, composition, and quantity of lipids in biological systems such …

Detailed knowledge on tissue-specific metabolic reprogramming in diabetic nephropathy
(DN) is vital for more accurate understanding the molecular pathological signature and …

In the last decades, surface‐assisted laser desorption/ionization mass spectrometry (SALDI‐
MS) has attracted increasing interest due to its unique capabilities, achievable through the …