Proliferating cell nuclear antigen (PCNA) is an essential factor in DNA replication and repair.
It forms a homotrimeric ring that embraces the DNA and slides along it, anchoring DNA …

In eukaryotes, DNA polymerase δ (Pol δ) bound to the proliferating cell nuclear antigen
(PCNA) replicates the lagging strand and cooperates with flap endonuclease 1 (FEN1) to …

Numerous eukaryotic DNA processing enzymes, such as DNA polymerases and ligases,
bind the processivity factor PCNA, which acts as a platform to recruit and regulate the …

GTSE1 is well correlated with tumor progression; however, little is known regarding its role
in liver cancer prognosis. By analyzing the hepatocellular carcinoma (HCC) datasets in GEO …

Proliferating cell nuclear antigen (PCNA) is an excellent inhibition target to shut down highly
proliferative cells and thereby develop a broad‐spectrum cancer therapeutic. It interacts with …

Interaction of PCNA with DNA polymerase is vital to efficient and processive DNA synthesis.
PCNA being a homotrimeric ring possesses three hydrophobic pockets mostly involved in …

DNA replication stress threatens ordinary DNA synthesis. The evolutionarily conserved DNA
replication stress response pathway involves sensor kinase Mec1/ATR, adaptor protein …

The coordination of enzymes and regulatory proteins for eukaryotic DNA replication and
repair is largely achieved by Proliferating Cell Nuclear Antigen (PCNA), a toroidal …

NMR spectroscopy offers unique benefits for ligand binding studies on isotopically labelled
target proteins. These benefits include atomic resolution, direct distinction of binding sites …

The sliding clamp PCNA is a key player in eukaryotic genome replication and stability,
acting as a platform onto which components of the DNA replication and repair machinery are …