Duchenne muscular dystrophy is a severe, progressive, muscle-wasting disease that leads
to difficulties with movement and, eventually, to the need for assisted ventilation and …

A large and complex gene on the X chromosome encodes dystrophin. Many mutations have
been described in this gene, most of which affect the expression of the muscle isoform, the …

The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations
in the gene encoding dystrophin. There is currently no effective treatment for the disease; …

Duchenne muscular dystrophy (DMD) is a muscular dystrophy with high incidence of
learning and behavioural problems and is associated with neurodevelopmental disorders …

Duchenne muscular dystrophy (DMD) is caused by frameshift mutations in the DMD gene
that prevent the body-wide translation of its protein product, dystrophin. Besides a severe …

Duchenne and Becker muscular dystrophies are caused by defects of the dystrophin gene.
Expression of this large X-linked gene is under elaborate transcriptional and splicing control …

Filamins are a family of high molecular mass cytoskeletal proteins that organize filamentous
actin in networks and stress fibers. Over the past few years it has become clear that filamins …

The largest known gene is the human dystrophin gene, which has 79 exons spanning at
least 2,300 kilobases (kb). Transcript accumulation was monitored from four regions of the …

Context The schizophrenia-susceptibility gene dysbindin (DTNBP1on 6p22. 3) encodes a
neuronal protein that binds to β-dystrobrevin and may be part of the dystrophin protein …

The mdx mouse, which carries a nonsense mutation in exon 23 of the dystrophin gene, has
been used as an animal model of Duchenne muscular dystrophy to evaluate cell or gene …