The principles of green chemistry (GC) can be comprehensively implemented in green
synthesis of pharmaceuticals by choosing no solvents or green solvents (preferably water) …

Borrowing hydrogen is a process that is used to diversify the synthetic utility of commodity
alcohols. A catalyst first oxidizes an alcohol by removing hydrogen to form a reactive …

Transition-metal catalyzed reactions that are able to construct complex aliphatic amines from
simple, readily available feedstocks have become a cornerstone of modern synthetic …

Since its advent two decades ago, asymmetric organo/transition-metal combined catalysis
(AOMC), including cooperative catalysis and relay catalysis, has leveraged redistribution of …

Direct substitution of readily available alcohols is recognized as a key research area in
green chemical synthesis. Starting from simple racemic secondary alcohols, the …

The borrowing hydrogen (BH) principle, also called hydrogen auto-transfer, is a powerful
approach which combines transfer hydrogenation (avoiding the direct use of molecular …

In 2007 the members of the ACS Green Chemistry Institute® Pharmaceutical Roundtable
assembled a list of key green chemistry research areas to both identify transformations that …

Enantioconvergent catalysis has expanded asymmetric synthesis to new methodologies
able to convert racemic compounds into a single enantiomer. This review covers recent …

Borrowing hydrogen or the hydrogen autotransfer amination is a powerful approach to
create single C–N bonds, starting from stable and readily available substrates: amines and …

The activation of a substrate by a chiral catalyst is now regarded as one of the most powerful
strategies that can be employed in the art of asymmetric synthesis. 1 The development of …