Wiskott‐Aldrich syndrome: a comprehensive review

MJ Massaad, N Ramesh… - Annals of the New York …, 2013 - Wiley Online Library
Wiskott‐Aldrich syndrome (WAS) is a rare X‐linked primary immunodeficiency characterized
by microthrombocytopenia, eczema, recurrent infections, and an increased incidence of …

Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease

HH Uhlig - Gut, 2013 - gut.bmj.com
Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, has
multifactorial aetiology with complex interactions between genetic and environmental …

Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome

A Aiuti, L Biasco, S Scaramuzza, F Ferrua, MP Cicalese… - Science, 2013 - science.org
Introduction Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency characterized
by eczema, thrombocytopenia, infections, and a high risk of developing autoimmunity and …

Outcomes following gene therapy in patients with severe Wiskott-Aldrich syndrome

SHB Abina, HB Gaspar, J Blondeau, L Caccavelli… - Jama, 2015 - jamanetwork.com
Importance Wiskott-Aldrich syndrome is a rare primary immunodeficiency associated with
severe microthrombocytopenia. Partially HLA antigen–matched allogeneic hematopoietic …

Animal models of inflammatory bowel disease

A Mizoguchi - Progress in molecular biology and translational …, 2012 - Elsevier
Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory condition that is
medicated by genetic, immune, and environmental factors. At least 66 different kinds of …

WASP: a key immunological multitasker

AJ Thrasher, SO Burns - Nature Reviews Immunology, 2010 - nature.com
Abstract The Wiskott–Aldrich syndrome protein (WASP) is an important regulator of the actin
cytoskeleton that is required for many haematopoietic and immune cell functions, including …

Regulatory lymphocytes and intestinal inflammation

A Izcue, JL Coombes, F Powrie - Annual review of immunology, 2009 - annualreviews.org
The immune system is pivotal in mediating the interactions between host and microbiota that
shape the intestinal environment. Intestinal homeostasis arises from a highly dynamic …

The wiskott-aldrich syndrome

HD Ochs, AJ Thrasher - Journal of Allergy and Clinical Immunology, 2006 - Elsevier
The Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder with variable clinical
phenotypes that correlate with the type of mutations in the WAS protein (WASP) gene …

Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy?

BC Melnik, SM John, G Schmitz - Journal of translational medicine, 2014 - Springer
Epidemiological evidence confirmed that raw cow's milk consumption in the first year of life
protects against the development of atopic diseases and increases the number of regulatory …

Recent advances in understanding the pathophysiology of Wiskott-Aldrich syndrome

M Bosticardo, F Marangoni, A Aiuti… - Blood, The Journal …, 2009 - ashpublications.org
Wiskott-Aldrich syndrome (WAS) is a severe X-linked immunodeficiency caused by
mutations in the gene encoding for WASP, a key regulator of signaling and cytoskeletal …