Platelets are the primary cellular mediators of hemostasis and this function firmly acquaints
them with a variety of inflammatory processes. For example, platelets can act as circulating …

Over the past decade, remarkable advances have been witnessed in the development of
small-molecule probes. These molecular tools have been widely applied for interrogating …

B-cell lymphoma extra large (BCL-XL) is a well-validated cancer target. However, the on-
target and dose-limiting thrombocytopenia limits the use of BCL-XL inhibitors, such as …

Tumor-educated blood platelets (TEPs) are implicated as central players in the systemic and
local responses to tumor growth, thereby altering their RNA profile. We determined the …

Proteolysis targeting chimera (PROTAC), hijacking protein of interest (POI) and recruiting E3
ligase for target degradation via the ubiquitin-proteasome pathway, is a novel drug …

Abstract Human MutT Homolog 1 (MTH1) is a nucleotide pool sanitization enzyme that
hydrolyzes oxidized nucleotides to prevent their mis-incorporation into DNA under oxidative …

Small molecules that selectively kill senescent cells (SCs), termed senolytics, have the
potential to prevent and treat various age-related diseases and extend healthspan. The use …

Cancer patients benefit from early tumor detection since treatment outcomes are more
favorable for less advanced cancers. Platelets are involved in cancer progression and are …

Two decades after the discovery of the first animal microRNA (miRNA), the number of
miRNAs in animal genomes remains a vexing question. Here, we report findings from …

Blood-based liquid biopsies, including tumor-educated blood platelets (TEPs), have
emerged as promising biomarker sources for non-invasive detection of cancer. Here we …