Aptamers are single-stranded nucleic acid molecules that possess properties comparable to
those of protein monoclonal antibodies, and thus are clear alternatives to long established …

RNA molecules play important and diverse regulatory roles in the cell by virtue of their
interaction with other nucleic acids, proteins and small molecules. Inspired by this natural …

The widespread natural ability of RNA to sense small molecules and regulate genes has
become an important tool for synthetic biology in applications as diverse as environmental …

Riboswitches are regulatory RNA elements typically located in the 5′-untranslated region
of certain mRNAs and control gene expression at the level of transcription or translation …

RNA regulators are emerging as powerful tools to engineer synthetic genetic networks or
rewire existing ones. A potential strength of RNA networks is that they may be able to …

Riboswitches are natural RNA-based genetic switches that sense small-molecule
metabolites and regulate in response the expression of the corresponding metabolic genes …

Our current understanding of biology suggests that early life relied predominantly on RNA
for catalysis and replication. Here, we report the isolation of an RNA polymerase ribozyme …

Small activating RNAs (saRNAs) targeting specific promoter regions are able to stimulate
gene expression at the transcriptional level, a phenomenon known as RNA activation …

Directed evolution has become a full-grown tool in molecular biology nowadays. The
methods that are involved in creating a mutant library are extensive and can be divided into …

Antisense RNA transcription attenuators are a key component of the synthetic biology
toolbox, with their ability to serve as building blocks for both signal integration logic circuits …